A new approach to access difluoroalkylated diarylmethanes via visible-light photocatalytic cross-coupling reactions

被引：69
|
作者：
Zhao, Yin-Na [1 ]
Luo, Yong-Chun [1 ]
Wang, Zhu-Yin [1 ]
Xu, Peng-Fei [1 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 32期
关键词：
PARA-QUINONE METHIDES; ARYL BORONIC ACIDS; ASYMMETRIC 1,6-CONJUGATE ADDITION; PHOTOREDOX CATALYSIS; ALPHA-ALKYLATION; EXPEDIENT ACCESS; PALLADIUM; RADICALS; ALDEHYDES; ARENES;
D O I：
10.1039/c8cc01486h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Difluoroalkylated diarylmethanes with biological and pharmacological potentials were synthesized from para-quinone methides (p-QMs) and difluoroalkylating reagents via a visible light photocatalysis strategy. Mechanism studies showed that the excited photocatalyst, *fac-Ir(ppy)(3), was primarily quenched by p-QMs and the generated diarylmethane radical intermediates then underwent a radical-radical cross-coupling reaction with difluoroalkyl radicals. This reaction features mild conditions, high efficiency and wide functional group compatibility.
引用
收藏
页码：3993 / 3996
页数：4
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