A new approach to access difluoroalkylated diarylmethanes via visible-light photocatalytic cross-coupling reactions

被引：70

作者：

Zhao, Yin-Na ^{[1
]}

Luo, Yong-Chun ^{[1
]}

Wang, Zhu-Yin ^{[1
]}

Xu, Peng-Fei ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 32期

关键词：

PARA-QUINONE METHIDES; ARYL BORONIC ACIDS; ASYMMETRIC 1,6-CONJUGATE ADDITION; PHOTOREDOX CATALYSIS; ALPHA-ALKYLATION; EXPEDIENT ACCESS; PALLADIUM; RADICALS; ALDEHYDES; ARENES;

D O I：

10.1039/c8cc01486h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Difluoroalkylated diarylmethanes with biological and pharmacological potentials were synthesized from para-quinone methides (p-QMs) and difluoroalkylating reagents via a visible light photocatalysis strategy. Mechanism studies showed that the excited photocatalyst, *fac-Ir(ppy)(3), was primarily quenched by p-QMs and the generated diarylmethane radical intermediates then underwent a radical-radical cross-coupling reaction with difluoroalkyl radicals. This reaction features mild conditions, high efficiency and wide functional group compatibility.

引用

页码：3993 / 3996

页数：4

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