Elevated mean platelet volume is associated with silent cerebral infarction

被引：35
作者：
Li, B. [1 ]
Liu, X. [2 ]
Cao, Z. -G. [3 ]
Li, Y. [2 ,4 ]
Liu, T. -M. [5 ]
Wang, R. -T. [2 ]
机构：
[1] Harbin Med Univ, Affiliated Hosp 2, Dept Neurol, Harbin 150086, Heilongjiang, Peoples R China
[2] Harbin Med Univ, Affiliated Hosp 2, Dept Geriatr, Harbin 150086, Heilongjiang, Peoples R China
[3] Harbin Med Univ, Affiliated Hosp 2, Dept Med Imaging, Harbin 150086, Heilongjiang, Peoples R China
[4] Harbin Med Univ, Affiliated Hosp 2, Int Phys Examinat & Hlth Ctr, Harbin 150086, Heilongjiang, Peoples R China
[5] UT Southwestern Med Ctr, Dept Internal Med, Div Hypothalam Res, Dallas, TX USA
来源：
INTERNAL MEDICINE JOURNAL | 2014年 / 44卷 / 07期
基金：
中国博士后科学基金;
关键词：
silent cerebral infarction; mean platelet volume; atherosclerosis; platelet activation; risk factor; ARTERIAL STIFFNESS; BRAIN INFARCTS; METABOLIC SYNDROME; RISK-FACTOR; DISEASE; STROKE; HEMODIALYSIS; ACTIVATION; EVENTS;
D O I：
10.1111/imj.12454
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: The presence of silent cerebral infarction (SCI) increases the risk of transient ischaemia attack, symptomatic stroke, cardiovascular disease and dementia. Mean platelet volume (MPV) is a surrogate marker of activated platelets and is considered a link between inflammation and thrombosis. In addition, MPV is a risk predictor for cardiovascular disease, stroke and overall vascular mortality. Aims: The purpose of the study was to assess the MPV levels in SCI patients. Methods: A cross-sectional study was conducted to evaluate the association between MPV and SCI in 2215 subjects (1385 men and 830 women). Results: The participants with SCI had higher MPV levels than those without SCI (10.4 +/- 1.3 fL vs. 9.2 +/- 1.2 fL; P < 0.001). Moreover, the subjects with a high MPV had a higher prevalence of SCI. Multivariate logistic regression analyses revealed that the odds ratios and 95% confidence intervals for SCI according to MPV quartiles were 1.000, 2.131 (1.319-3.444), 3.015 (1.896-4.794), 7.822 (4.874-12.554) respectively (P < 0.001). Conclusion: MPV is a novel index for SCI regardless of classical cardiovascular risk factors.
引用
收藏
页码：653 / 657
页数：5
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