Copper-Catalyzed Direct Trifluoromethylation of Propiolates: Construction of Trifluoromethylated Coumarins

被引：150

作者：

Li, Yuewen ^{[1
,2
]}

Lu, Yuan ^{[3
]}

Qiu, Guanyinsheng ^{[4
]}

Ding, Qiuping ^{[1
,2
]}

机构：

[1] Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China

[2] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China

[3] Fudan Univ, Obstet & Gynecol Hosp, Shanghai 200011, Peoples R China

[4] Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing 314001, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 16期

基金：

中国国家自然科学基金;

关键词：

OLEFINIC TRIFLUOROMETHYLATION; RADICAL TRIFLUOROMETHYLATION; PERFLUOROALKYL IODIDES; MEDICINAL CHEMISTRY; BUILDING-BLOCKS; ALKENES; EFFICIENT; OXYTRIFLUOROMETHYLATION; FLUORINE; CARBOTRIFLUOROMETHYLATION;

D O I：

10.1021/ol501939m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel copper-catalyzed direct trifluoromethylation of internal alkynes was developed, obtaining a series of trifluoromethylated coumarins in good yields. The cyclization was proposed to proceed via a radical mechanism under copper-catalyzed conditions with good functional group tolerance.

引用

页码：4240 / 4243

页数：4

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