Copper-Catalyzed Direct Trifluoromethylation of Propiolates: Construction of Trifluoromethylated Coumarins

被引：150
作者：
Li, Yuewen [1 ,2 ]
Lu, Yuan [3 ]
Qiu, Guanyinsheng [4 ]
Ding, Qiuping [1 ,2 ]
机构：
[1] Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China
[2] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China
[3] Fudan Univ, Obstet & Gynecol Hosp, Shanghai 200011, Peoples R China
[4] Jiaxing Univ, Coll Biol Chem Sci & Engn, Jiaxing 314001, Zhejiang, Peoples R China
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 16期
基金：
中国国家自然科学基金;
关键词：
OLEFINIC TRIFLUOROMETHYLATION; RADICAL TRIFLUOROMETHYLATION; PERFLUOROALKYL IODIDES; MEDICINAL CHEMISTRY; BUILDING-BLOCKS; ALKENES; EFFICIENT; OXYTRIFLUOROMETHYLATION; FLUORINE; CARBOTRIFLUOROMETHYLATION;
D O I：
10.1021/ol501939m
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel copper-catalyzed direct trifluoromethylation of internal alkynes was developed, obtaining a series of trifluoromethylated coumarins in good yields. The cyclization was proposed to proceed via a radical mechanism under copper-catalyzed conditions with good functional group tolerance.
引用
收藏
页码：4240 / 4243
页数：4
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