Emerging role of IL-17 and Th17 cells in systemic lupus erythematosus

被引：119

作者：

Martin, Jerome C. ^{[1
,2
,3
]}

Baeten, Dominique L. ^{[4
]}

Josien, Regis ^{[1
,2
,3
]}

机构：

[1] CHU Nantes, Immunol Lab, F-44000 Nantes, France

[2] ITUN, INSERM UMR1064, Nantes, France

[3] Univ Nantes, Sch Med, Nantes, France

[4] Univ Amsterdam, Acad Med Ctr, Dept Clin Immunol & Rheumatol, NL-1105 AZ Amsterdam, Netherlands

来源：

CLINICAL IMMUNOLOGY | 2014年 / 154卷 / 01期

关键词：

IL-17; Th17; SLE; INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; T-HELPER-CELLS; ROR-GAMMA-T; CHRONIC MUCOCUTANEOUS CANDIDIASIS; ACTIVE PSORIATIC-ARTHRITIS; GROWTH-FACTOR-BETA; PROOF-OF-CONCEPT; DOUBLE-BLIND; DENDRITIC CELLS; T(H)17 CELLS;

D O I：

10.1016/j.clim.2014.05.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite the success of targeted therapies in managing immune-mediated inflammatory diseases (IMIDs) such as RA, IBDs, MS and psoriasis, unmet needs for such approach in SLE are widely recognized. In the past 2 years, exciting insights supporting previous lines of evidence on the role of the IL-23/IL-17 axis in SLE have emerged. This is of particular importance as IL-17 blockers have now moved successfully into the clinical space, as illustrated in psoriasis and ankylosing spondylitis. However, recent fundamental studies also highlighted unexPected aspects of IL-17/Th17 biology whose comprehension may prevent disappointing results of IL-17 targeting such as those obtained in Crohn's disease. Therefore, establishing a current picture of the IL-17 pre-clinical situation in SLE is timely in order to plan future proof-of-concept studies in human. (C) 2014 Published by Elsevier Inc.

引用

页码：1 / 12

页数：12

共 142 条

[1] Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells [J].

Acosta-Rodriguez, Eva V. ;

Rivino, Laura ;

Geginat, Jens ;

Jarrossay, David ;

Gattorno, Marco ;

Lanzavecchia, Antonio ;

Sallusto, Federica ;

Napolitani, Giorgio .

NATURE IMMUNOLOGY, 2007, 8 (06) :639-646

[2] DECREASED PRODUCTION OF AND RESPONSE TO INTERLEUKIN-2 BY CULTURED LYMPHOCYTES FROM PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

ALCOCERVARELA, J ;

ALARCONSEGOVIA, D .

JOURNAL OF CLINICAL INVESTIGATION, 1982, 69 (06) :1388-1392

[3] Analysis of IL-17+ cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response [J].

Appel, Heiner ;

Maier, Rene ;

Wu, Peihua ;

Scheer, Rebecca ;

Hempfing, Axel ;

Kayser, Ralph ;

Thiel, Andreas ;

Radbruch, Andreas ;

Loddenkemper, Christoph ;

Sieper, Joachim .

ARTHRITIS RESEARCH & THERAPY, 2011, 13 (03)

[4] Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial [J].

Baeten, Dominique ;

Baraliakos, Xenofon ;

Braun, Juergen ;

Sieper, Joachim ;

Emery, Paul ;

van der Heijde, Desiree ;

McInnes, Iain ;

van Laar, Jacob M. ;

Landewe, Robert ;

Wordsworth, Paul ;

Wollenhaupt, Juergen ;

Kellner, Herbert ;

Paramarta, Jacqueline ;

Wei, Jiawei ;

Brachat, Arndt ;

Bek, Stephan ;

Laurent, Didier ;

Li, Yali ;

Wang, Ying A. ;

Bertolino, Arthur P. ;

Gsteiger, Sandro ;

Wright, Andrew M. ;

Hueber, Wolfgang .

LANCET, 2013, 382 (9906) :1705-1713

[5] Interleukin-17 and a tale of two autoimmune diseases [J].

Baeten, Dominique L. P. ;

Kuchroo, Vijay K. .

NATURE MEDICINE, 2013, 19 (07) :824-825

[6] Nucleic acids of mammalian origin can act as endogenous ligands for toll-like receptors and may promote systemic lupus erythematosus [J].

Barrat, FJ ;

Meeker, T ;

Gregorio, J ;

Chan, JH ;

Uematsu, S ;

Akira, S ;

Chang, B ;

Duramad, O ;

Coffman, RL .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (08) :1131-1139

[7] Interferon and granulopoiesis signatures in systemic lupus erythematosus blood [J].

Bennett, L ;

Palucka, AK ;

Arce, E ;

Cantrell, V ;

Borvak, J ;

Banchereau, J ;

Pascual, V .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (06) :711-723

[8] Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells [J].

Bettelli, E ;

Carrier, YJ ;

Gao, WD ;

Korn, T ;

Strom, TB ;

Oukka, M ;

Weiner, HL ;

Kuchroo, VK .

NATURE, 2006, 441 (7090) :235-238

[9] Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus [J].

Blanco, P ;

Palucka, AK ;

Gill, M ;

Pascual, V ;

Banchereau, J .

SCIENCE, 2001, 294 (5546) :1540-1543

[10] An ACT1 Mutation Selectively Abolishes Interleukin-17 Responses in Humans with Chronic Mucocutaneous Candidiasis [J].

Boisson, Bertrand ;

Wang, Chenhui ;

Pedergnana, Vincent ;

Wu, Ling ;

Cypowyj, Sophie ;

Rybojad, Michel ;

Belkadi, Aziz ;

Picard, Capucine ;

Abel, Laurent ;

Fieschi, Claire ;

Puel, Anne ;

Li, Xiaoxia ;

Casanova, Jean-Laurent .

IMMUNITY, 2013, 39 (04) :676-686

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