Folic Acid/Methotrexate Functionalized Mesoporous Silica Nanoflakes from Different Supports: Comparative Study

被引:5
|
作者
Trukawka, Martyna [1 ]
Cendrowski, Krzysztof [1 ]
Konicki, Wojciech [2 ]
Mijowska, Ewa [1 ]
机构
[1] West Pomeranian Univ Technol, Fac Chem Technol & Engn, Dept Nanomat Physicochem, Piastow Ave 42, PL-71065 Szczecin, Poland
[2] Maritime Univ Szczecin, Dept Integrated Transport Technol & Environm Prot, H Poboznego St 11, PL-70507 Szczecin, Poland
来源
APPLIED SCIENCES-BASEL | 2020年 / 10卷 / 18期
关键词
silica flakes; anticancer drugs; targeted therapy; drug carrier; multifunctional drugs; folic acid; methotrexate; PORE-SIZE; IN-VITRO; DEGRADATION BEHAVIOR; CELLULAR UPTAKE; DRUG-DELIVERY; NANOPARTICLES; ACID; ADSORPTION; MORPHOLOGY; PLATFORM;
D O I
10.3390/app10186465
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Herein, we present a facile synthesis route for the mesoporous silica nanoflakes on two types of templates and evaluate their potential as potential drug delivery systems. Silica materials are attractive due to their biocompatibility, low cytotoxicity, high surface area, and tunable pores. In addition, they can be multifunctionalized. These properties were used to create multifunctional drug delivery systems combining folic acid as a target molecule and methotrexate (MTX) as an anticancer drug. The silica nanoflakes were formed using graphene oxide and double-layered hydroxide as templates, respectively. After the removal of matrices, the silica flakes were functionalized by folic acid and loaded with methotrexate. The differences in drug release performance and structural stability were analyzed with respect to the detailed physicochemical characterization of the produced silica nanoflakes.
引用
收藏
页数:14
相关论文
共 50 条
  • [21] Folic Acid and PEI Modified Mesoporous Silica for Targeted Delivery of Curcumin
    Sun, Xiaoxiao
    Wang, Nan
    Yang, Li-Ye
    Ouyang, Xiao-Kun
    Huang, Fangfang
    PHARMACEUTICS, 2019, 11 (09)
  • [22] Adsorption of Acid Dyes by Functionalized SBA-15 Mesoporous Silica of Different Pore Lengths
    Lee, Jan-Yen
    Chen, Chia-Han
    Cheng, Soofin
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2015, 62 (06) : 483 - 494
  • [23] Functionalized mesoporous materials for adsorption and release of different drug molecules: A comparative study
    Wang, Gang
    Otuonye, Amy N.
    Blair, Elizabeth A.
    Denton, Kelley
    Tao, Zhimin
    Asefa, Tewodros
    JOURNAL OF SOLID STATE CHEMISTRY, 2009, 182 (07) : 1649 - 1660
  • [24] Nickel hexacyanoferrate multilayers on functionalized mesoporous silica supports for selective sorption and sensing of cesium
    Chang, Chin-Yuan
    Chau, Lai-Kwan
    Hu, Wei-Ping
    Wang, Chiou-Yann
    Liao, Ju-Hsiou
    MICROPOROUS AND MESOPOROUS MATERIALS, 2008, 109 (1-3) : 505 - 512
  • [25] Preparation and catalytic performance of phenylsulfonic acid functionalized mesoporous silica
    Yang, JM
    Kou, LG
    Lü, J
    ACTA CHIMICA SINICA, 2005, 63 (05) : 396 - 400
  • [26] Esterification of guaiacol with octanoic acid over functionalized mesoporous silica
    Xu, Xiwei
    Jiang, Enchen
    Lei, Zhiwei
    RENEWABLE ENERGY, 2018, 119 : 439 - 446
  • [27] Mesoporous silica nanoparticles prepared by different methods for biomedical applications: Comparative study
    Ashour, Mohamed M.
    Mabrouk, Mostafa
    Soliman, Islam E.
    Beherei, Hanan H.
    Tohamy, Khairy M.
    IET NANOBIOTECHNOLOGY, 2021, 15 (03) : 291 - 300
  • [28] Comparison of two different folic acid doses with methotrexate – a randomized controlled trial (FOLVARI Study)
    Varun Dhir
    Amit Sandhu
    Jasbinder Kaur
    Benzeeta Pinto
    Phani Kumar
    Prabhdeep Kaur
    Nidhi Gupta
    Ankita Sood
    Aman Sharma
    Shefali Sharma
    Arthritis Research & Therapy, 17
  • [29] Comparison of two different folic acid doses with methotrexate - a randomized controlled trial (FOLVARI Study)
    Dhir, Varun
    Sandhu, Amit
    Kaur, Jasbinder
    Pinto, Benzeeta
    Kumar, Phani
    Kaur, Prabhdeep
    Gupta, Nidhi
    Sood, Ankita
    Sharma, Aman
    Sharma, Shefali
    ARTHRITIS RESEARCH & THERAPY, 2015, 17
  • [30] COMPARISON OF TWO DIFFERENT FOLIC ACID DOSES WITH METHOTREXATE - A RANDOMIZED CONTROLLED TRIAL (FOLVARI STUDY)
    Sandhu, A.
    Kaur, J.
    Pinto, B.
    Kumar, P.
    Gupta, N.
    Kaur, P.
    Sood, A.
    Sharma, A.
    Sharma, S.
    Dhir, V
    INTERNAL MEDICINE JOURNAL, 2015, 45 : 33 - 33