Folic Acid/Methotrexate Functionalized Mesoporous Silica Nanoflakes from Different Supports: Comparative Study

被引:5
|
作者
Trukawka, Martyna [1 ]
Cendrowski, Krzysztof [1 ]
Konicki, Wojciech [2 ]
Mijowska, Ewa [1 ]
机构
[1] West Pomeranian Univ Technol, Fac Chem Technol & Engn, Dept Nanomat Physicochem, Piastow Ave 42, PL-71065 Szczecin, Poland
[2] Maritime Univ Szczecin, Dept Integrated Transport Technol & Environm Prot, H Poboznego St 11, PL-70507 Szczecin, Poland
来源
APPLIED SCIENCES-BASEL | 2020年 / 10卷 / 18期
关键词
silica flakes; anticancer drugs; targeted therapy; drug carrier; multifunctional drugs; folic acid; methotrexate; PORE-SIZE; IN-VITRO; DEGRADATION BEHAVIOR; CELLULAR UPTAKE; DRUG-DELIVERY; NANOPARTICLES; ACID; ADSORPTION; MORPHOLOGY; PLATFORM;
D O I
10.3390/app10186465
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Herein, we present a facile synthesis route for the mesoporous silica nanoflakes on two types of templates and evaluate their potential as potential drug delivery systems. Silica materials are attractive due to their biocompatibility, low cytotoxicity, high surface area, and tunable pores. In addition, they can be multifunctionalized. These properties were used to create multifunctional drug delivery systems combining folic acid as a target molecule and methotrexate (MTX) as an anticancer drug. The silica nanoflakes were formed using graphene oxide and double-layered hydroxide as templates, respectively. After the removal of matrices, the silica flakes were functionalized by folic acid and loaded with methotrexate. The differences in drug release performance and structural stability were analyzed with respect to the detailed physicochemical characterization of the produced silica nanoflakes.
引用
收藏
页数:14
相关论文
共 50 条
  • [1] Encapsulation of folic acid in different silica porous supports: A comparative study
    Perez-Esteve, Edgar
    Ruiz-Rico, Maria
    de la Torre, Cristina
    Villaescusa, Luis A.
    Sancenon, Felix
    Marcos, Maria D.
    Amoros, Pedro
    Martinez-Manez, Ramon
    Manuel Barat, Jose
    FOOD CHEMISTRY, 2016, 196 : 66 - 75
  • [2] Mesoporous silica materials functionalized with folic acid: preparation, characterization and release profile study with methotrexate
    Luiza Baptista de Oliveira Freitas
    Ismael José Gonzalez Bravo
    Waldemar Augusto de Almeida Macedo
    Edésia Martins Barros de Sousa
    Journal of Sol-Gel Science and Technology, 2016, 77 : 186 - 204
  • [3] Mesoporous silica materials functionalized with folic acid: preparation, characterization and release profile study with methotrexate
    de Oliveira Freitas, Luiza Baptista
    Gonzalez Bravo, Ismael Jose
    de Almeida Macedo, Waldemar Augusto
    Barros de Sousa, Edesia Martins
    JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY, 2016, 77 (01) : 186 - 204
  • [4] A comparative study on different functionalized mesoporous silica nanomagnetic sorbents for efficient extraction of parabens
    Mehdinia, Ali
    Bahrami, Mahnaz
    Mozaffari, Shahla
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2015, 12 (09) : 1543 - 1552
  • [5] A comparative study on different functionalized mesoporous silica nanomagnetic sorbents for efficient extraction of parabens
    Ali Mehdinia
    Mahnaz Bahrami
    Shahla Mozaffari
    Journal of the Iranian Chemical Society, 2015, 12 : 1543 - 1552
  • [6] Mesoporous silica nanoparticles functionalized with folic acid/methionine for active targeted delivery of docetaxel
    Khosravian, Pegah
    Ardestani, Mehdi Shafiee
    Khoobi, Mehdi
    Ostad, Seyed Naser
    Dorkoosh, Farid Abedin
    Javar, Hamid Akbari
    Amanlou, Massoud
    ONCOTARGETS AND THERAPY, 2016, 9 : 7315 - 7330
  • [7] Folic Acid-Polyethyleneimine Functionalized Mesoporous Silica Nanoparticles as a Controlled Release Nanocarrier
    Park, Jihye
    Park, Sung Soo
    Jo, Nam-Ju
    Ha, Chang-Sik
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2019, 19 (10) : 6217 - 6224
  • [8] BIOCATALYSTS OBTAINED BY ENZYME IMMOBILIZATION ON FUNCTIONALIZED MESOPOROUS SILICA SUPPORTS
    Filip, Mihaela
    Mureseanu, Mihaela
    Paun, Gabriela
    Parvulescu, Viorica
    REVUE ROUMAINE DE CHIMIE, 2016, 61 (11-12) : 927 - 933
  • [9] Mesoporous silica nanoparticles functionalized with folic acid for targeted release Cis-Pt to glioblastoma cells
    Ortiz-Islas, Emma
    Sosa-Arroniz, Anahi
    Elena Manriquez-Ramirez, Ma
    Ekaterina Rodriguez-Perez, C.
    Tzompantzi, Francisco
    Manuel Padilla, Juan
    REVIEWS ON ADVANCED MATERIALS SCIENCE, 2021, 60 (01) : 25 - 37
  • [10] Mesoporous silica-coated quantum dots functionalized with folic acid for lung cancer cell imaging
    Zhou, Shang
    Huo, Danqun
    Hou, Changjun
    Yang, Mei
    Fa, Huanbao
    Xia, Cui
    Chen, Mei
    ANALYTICAL METHODS, 2015, 7 (22) : 9649 - 9654