Effects of dietary wheat bran arabinoxylans on cholesterol metabolism of hypercholesterolemic hamsters

被引：51

作者：

Tong, Li-Tao ^{[1
]}

Zhong, Kui ^{[1
]}

Liu, Liya ^{[1
]}

Qiu, Ju ^{[2
]}

Guo, Lina ^{[1
]}

Zhou, Xianrong ^{[1
]}

Cao, Li ^{[3
,4
]}

Zhou, Sumei ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Inst Agroprod Proc Sci & Technol, Lab Agroprod Proc, Minist Agr, Beijing 100193, Peoples R China

[2] Inst Food & Nutr Dev, Minist Agr, Beijing 100081, Peoples R China

[3] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China

[4] Peking Union Med Coll, Beijing 100193, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2014年 / 112卷

基金：

中国国家自然科学基金; 对外科技合作项目（国际科技项目）;

关键词：

Wheat bran arabinoxylans; Oat beta-glucan; Hypercholesterolemia; Fecal lipids; Short-chain fatty acids; Hamsters; MESSENGER-RNA EXPRESSION; OAT BETA-GLUCAN; FERMENTABLE FIBER; RATS; CONSUMPTION; IMPROVES; HEALTH; LIPIDS;

D O I：

10.1016/j.carbpol.2014.05.061

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The aim of the present study is to investigate the effects of dietary wheat bran arabinoxylans (AXs) on cholesterol metabolism in hypercholesterolemic hamsters. The hamsters were divided into 3 groups and fed the experimental diets containing AXs or oat beta-glucan at a dose of 5 g/kg for 30 days. As the results, the AXs lowered plasma total cholesterol and LDL-cholesterol concentrations, and increased excretions of total lipids, cholesterol and bile acids, as well as oat beta-glucan. The AXs reduced the activity of 3-hydroxy-3-methyl glutaryl-coenzyme A (HMG-CoA) reductase, and increased the activity of cholesterol 7-alpha hydroxylase (CYP7A1) in liver. Moreover, the AXs increased propionate and the total short-chain fatty acids (SCFAs) concentrations. These results indicated that dietary AXs reduced the plasma total cholesterol and LDL-cholesterol concentrations by promoting the excretion of fecal lipids, regulating the activities of HMG-CoA reductase and CYP7A1, and increasing colonic SCFAs in hamsters. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1 / 5

页数：5

共 23 条

[1] Whole wheat and triticale flours with differing viscosities stimulate cecal fermentations and lower plasma and hepatic lipids in rats [J].

Adam, A ;

Levrat-Verny, MA ;

Lopez, HW ;

Leuillet, M ;

Demigné, C ;

Rémésy, C .

JOURNAL OF NUTRITION, 2001, 131 (06) :1770-1776

[2] Fermentation of various dietary fiber sources by human fecal bacteria [J].

Bourquin, LD ;

Titgemeyer, EC ;

Fahey, GC .

NUTRITION RESEARCH, 1996, 16 (07) :1119-1131

[3]

BRAATEN JT, 1994, EUR J CLIN NUTR, V48, P465

[4] Prebiotic and Other Health-Related Effects of Cereal-Derived Arabinoxylans, Arabinoxylan-Oligosaccharides, and Xylooligosaccharides [J].

Broekaert, Willem F. ;

Courtin, Christophe M. ;

Verbeke, Kristin ;

Van de Wiele, Tom ;

Verstraete, Willy ;

Delcour, Jan A. .

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2011, 51 (02) :178-194

[5] Antitumor and immunomodulatory activity of arabinoxylans: A major constituent of wheat bran [J].

Cao, Li ;

Liu, Xiuzhen ;

Qian, Tianxiu ;

Sun, Guibo ;

Guo, Yan ;

Chang, Fengjin ;

Zhou, Sumei ;

Sun, Xiaobo .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2011, 48 (01) :160-164

[6] The composition of dietary fibre-rich extrudates from oat affects bile acid binding and fermentation in vitro [J].

Drzikova, B ;

Dongowski, G ;

Gebhardt, E ;

Habel, A .

FOOD CHEMISTRY, 2005, 90 (1-2) :181-192

[7]

Fincher G. B., 1986, Advances in Cereal Science and Technology, V8, P207

[8] Arabinoxylan fibre consumption improved glucose metabolism, but did not affect serum adipokines in subjects with impaired glucose tolerance [J].

Garcia, A. L. ;

Steiniger, J. ;

Reich, S. C. ;

Weickert, M. O. ;

Harsch, I. ;

Machowetz, A. ;

Mohlig, M. ;

Spranger, J. ;

Rudovich, N. N. ;

Meuser, F. ;

Doerfer, J. ;

Katz, N. ;

Speth, M. ;

Zunft, H. J. F. ;

Pfeiffer, A. H. F. ;

Koebnick, C. .

HORMONE AND METABOLIC RESEARCH, 2006, 38 (11) :761-766

[9]

HASHIMOTO S, 1987, CEREAL CHEM, V64, P30

[10] Corn bran dietary fibre modified by xylanase improves the mRNA expression of genes involved in lipids metabolism in rats [J].

Hu, Ye-Bi ;

Wang, Zhang ;

Xu, Shi-Ying .

FOOD CHEMISTRY, 2008, 109 (03) :499-505

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