Selective delivery of curcumin to HER2/neu-overexpressing tumor cells using nanoscale oil body

被引：8

作者：

Chiang, Chung-Jen ^{[1
]}

Chen, Chin-Jung ^{[1
]}

Liou, Pei-Jie ^{[1
]}

Chao, Yun-Peng ^{[2
,3
,4
]}

机构：

[1] China Med Univ, Dept Med Lab Sci & Biotechnol, 91 Hsueh Shih Rd, Taichung 40402, Taiwan

[2] Feng Chia Univ, Dept Chem Engn, 100 Wenhwa Rd, Taichung 40724, Taiwan

[3] China Med Univ Hosp, Dept Med Res, Taichung 40447, Taiwan

[4] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 41354, Taiwan

来源：

JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS | 2019年 / 99卷

关键词：

Nanoscale oil body; Curcumin; HER2/neu; Targeted delivery; BREAST-CANCER CELLS; TARGETED DELIVERY; APOPTOSIS; ENCAPSULATION; NANOTECHNOLOGY; PROLIFERATION; ANGIOGENESIS; LIPOSOMES; MICELLES; HYBRID;

D O I：

10.1016/j.jtice.2019.03.013

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Curcumin (CCM) is a polyphenolic compound originating from the rhizome of Curcuma longa. In addition to its conventional use as food flavoring, CCM exhibits a high cytotoxic activity against a wide range of tumor cells. However, CCM has poor bioavailability due to its hydrophobic nature. In this study, nanoscale oil bodies (NOBs) were explored for the formulation of CCM. The one-step assembly of NOBs was carried out with CCM, plant oil, phospholipids, and the fusion protein consisting of oleosin and the anti-HER2/neu affibody. NOBs displayed the high encapsulation efficiency of and loading capacity of CCM. Moreover, it resulted in a strong anti-proliferative effect on HER2/neu-positive tumor cells which were administrated with the CCM-loaded NOBs. The result indicates the potential application of NOBs for targeted delivery of CCM. (C) 2019 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

引用

页码：38 / 44

页数：7

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