Sex differences in resting state neural networks of nicotine-dependent cigarette smokers

被引：32

作者：

Wetherill, Reagan R. ^{[1
]}

Jagannathan, Kanchana ^{[1
]}

Shin, Joshua ^{[1
]}

Franklin, Teresa R. ^{[1
]}

机构：

[1] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA

来源：

ADDICTIVE BEHAVIORS | 2014年 / 39卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Arterial spin labeling; Cerebral blood flow; Nicotine; Sex differences; Seed-based correlation analysis; CEREBRAL-BLOOD-FLOW; FUNCTIONAL CONNECTIVITY; TOBACCO ABSTINENCE; SMOKING-CESSATION; BRAIN NETWORKS; DRUG-ABUSE; ADDICTION; MRI;

D O I：

10.1016/j.addbeh.2014.01.006

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Although several sex differences in nicotine dependence have been identified, the neural mechanisms underlying these sex differences are not clear. The present study examines sex differences in resting-state brain activity using an arterial spin labeling (ASL) perfusion imaging technique. Fifty-one (31 males) sated nicotine-dependent cigarette smokers underwent perfusion functional magnetic resonance imaging during the resting state. Using functionally defined hippocampus/amygdala (HIP/AMY) seed regions, we observed sex differences in correlation strength between the HIP/AMY and the bilateral anterior insula, rostral anterior cingulate cortex, and inferior parietal lobule with females showing stronger functional coupling than males. This pattern of synchronous variations in dynamic cerebral blood flow is consistent with recent models of nicotine dependence, and as such, our findings provide a novel perspective on the neural mechanisms that may contribute to sex differences in nicotine dependence. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：789 / 792

页数：4

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