The Role of miR-210 in the Biological System: A Current Overview

被引：16

作者：

Hui, Xu ^{[1
]}

Al-Ward, Hisham ^{[1
]}

Shaher, Fahmi ^{[2
]}

Liu, Chun-Yang ^{[1
]}

Liu, Ning ^{[1
]}

机构：

[1] Jiamusi Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Jiamusi 154007, Peoples R China

[2] Jiamusi Univ, Sch Basic Med Sci, Dept Pathophysiol, Jiamusi, Peoples R China

来源：

HUMAN HEREDITY | 2020年 / 84卷 / 06期

基金：

中国国家自然科学基金;

关键词：

DNA repair; mRNA; Hypoxia; miR-210; Brain injury; INDUCIBLE FACTOR 1-ALPHA; CELL-CYCLE REGULATION; GENE-EXPRESSION; MICRORNA MIR-210; UP-REGULATION; BRAIN-INJURY; DNA-REPAIR; IN-VIVO; HYPOXIA; CANCER;

D O I：

10.1159/000509280

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: MicroRNAs (miRNAs) represent a group of non-coding RNAs measuring 19-23 nucleotides in length and are recognized as powerful molecules that regulate gene expression in eukaryotic cells. miRNAs stimulate the post-transcriptional regulation of gene expression via direct or indirect mechanisms. Summary: miR-210 is highly upregulated in cells under hypoxia, thereby revealing its significance to cell endurance. Induction of this mRNA expression is an important feature of the cellular low-oxygen response and the most consistent and vigorous target of HIF. Key Message: miR-210 is involved in many cellular functions under the effect of HIF-1 alpha, including the cell cycle, DNA repair, immunity and inflammation, angiogenesis, metabolism, and macrophage regulation. It also plays an important regulatory role in T-cell differentiation and stimulation.

引用

页码：233 / 239

页数：7

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