Chemical composition and possible use as adjuvant of the antibiotic therapy of the essential oil of Rosmarinus officinalis L.

被引：35

作者：

Barreto, Humberto M. ^{[1
]}

Silva Filho, Edson C. ^{[1
]}

Lima, Edeltrudes de O. ^{[2
]}

Coutinho, Henrique D. M. ^{[3
]}

Morais-Braga, Maria F. B. ^{[3
]}

Tavares, Cicera C. A. ^{[3
]}

Tintino, Saulo R. ^{[3
]}

Rego, Juciane V. ^{[4
]}

de Abreu, Aislan P. L. ^{[5
]}

Gomes Lustosa, Maria do Carmo ^{[5
]}

Guimaraes Oliveira, Roger Wallacy ^{[5
]}

Cito, Antonia M. G. L. ^{[6
]}

Dantas Lopes, Jose Arimateia ^{[6
]}

机构：

[1] Univ Fed Piaui, Microbiol Lab, Teresina, PI, Brazil

[2] Univ Fed Paraiba, Lab Micol, BR-58059900 Joao Pessoa, Paraiba, Brazil

[3] Univ Region Cariri, Lab Microbiol & Mol Biol, Crato, CE, Brazil

[4] Univ Fed Piaui, Lab Cellular & Mol Biol, Floriano, PI, Brazil

[5] FAESF, Microbiol Lab, Floriano, PI, Brazil

[6] Univ Fed Piaui, Lab Nat Prod, Teresina, PI, Brazil

来源：

INDUSTRIAL CROPS AND PRODUCTS | 2014年 / 59卷

关键词：

Rosmarinus officinalis L; Lamiaceae; Rosemary; Essential oil; Drug resistance modifying activity; ANTIMICROBIAL ACTIVITY; ANTIBACTERIAL ACTIVITY; ANTIOXIDANT PROPERTIES; MEDICINAL-PLANTS; ROSEMARY; RESISTANCE; AMINOGLYCOSIDES; COMBINATION; MECHANISMS; AUREUS;

D O I：

10.1016/j.indcrop.2014.05.026

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

Rosmarinus officinalis L (rosemary) essential oil (REO) was tested for its antimicrobial activity alone and in combination with conventional antibiotics used against Staphylococcus aureus, Escherichia coli, and Candida strains. The essential oil was chemically described using GC-MS analysis and its antibiotic-resistance modifying activity was assayed using microdilution method. A significant modulatory effect on the drug resistance was verified when the REO was used in association with aminoglycoside antibiotics against E. coli and S. aureus multidrug resistant strains. With respect to the antifungal tested, there was a decrease on amphotericin B activity when this antibiotic was tested in association with the REO against Candida krusei. On the other hand, the combined use of the REO with benzoilmetronidazole was more effective than the antibiotic alone when tested against C. krusei. Rosemary essential oil could become a promising source of metabolites with antibiotic-resistance modifying activity for use against multi-drug-resistant microorganisms. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：290 / 294

页数：5

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