Investigating the micro-rheology of the vitreous humor using an optically trapped local probe

被引：26

作者：

Watts, Fiona ^{[1
]}

Tan, Lay Ean ^{[2
,5
]}

Wilson, Clive G. ^{[2
]}

Girkin, John M. ^{[3
]}

Tassieri, Manlio ^{[4
]}

Wright, Amanda J. ^{[1
,6
]}

机构：

[1] Univ Strathclyde, Inst Photon, SUPA, Glasgow G4 0NW, Lanark, Scotland

[2] Univ Strathclyde, Strathclyde Inst Pharm & Biol Sci, Glasgow G4 0NR, Lanark, Scotland

[3] Univ Durham, Dept Phys, Biophys Sci Inst, Durham DH1 3LE, England

[4] Univ Glasgow, Sch Engn, Div Biomed Engn, Glasgow G12 8LT, Lanark, Scotland

[5] Ferring Controlled Therapeut Ltd, E Kilbride G74 5PB, Lanark, Scotland

[6] Univ Nottingham, IBIOS, Nottingham NG7 2RD, England

来源：

JOURNAL OF OPTICS | 2014年 / 16卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

optical trapping; micro-rheology; vitreous humor; COMPLEX FLUIDS; TWEEZERS; VISCOSITY; FORCE; MICRORHEOLOGY;

D O I：

10.1088/2040-8978/16/1/015301

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We demonstrate that an optically trapped silica bead can be used as a local probe to measure the micro-rheology of the vitreous humor. The Brownian motion of the bead was observed using a fast camera and the micro-rheology determined by analysis of the time-dependent mean-square displacement of the bead. We observed regions of the vitreous that showed different degrees of viscoelasticity, along with the homogeneous and inhomogeneous nature of different regions. The motivation behind this study is to understand the vitreous structure, in particular changes due to aging, allowing more confident prediction of pharmaceutical drug behavior and delivery within the vitreous humor.

引用

页数：7

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