Neural Activity in Human Hippocampal Formation Reveals the Spatial Context of Retrieved Memories

被引：235

作者：

Miller, Jonathan F. ^{[1
]}

Neufang, Markus ^{[2
]}

Solway, Alec ^{[3
]}

Brandt, Armin ^{[2
]}

Trippel, Michael ^{[2
]}

Mader, Irina ^{[2
]}

Hefft, Stefan ^{[2
]}

Merkow, Max ^{[3
]}

Polyn, Sean M. ^{[3
]}

Jacobs, Joshua ^{[1
]}

Kahana, Michael J. ^{[3
]}

Schulze-Bonhage, Andreas ^{[2
]}

机构：

[1] Drexel Univ, Philadelphia, PA 19104 USA

[2] Univ Med Ctr, Epilepsy Ctr, Freiburg, Germany

[3] Univ Penn, Philadelphia, PA 19104 USA

来源：

SCIENCE | 2013年 / 342卷 / 6162期

关键词：

PLACE CELLS; PATH-INTEGRATION; THETA RHYTHM; FREE-RECALL; SEARCH; NAVIGATION; NEURONS; PATTERNS; MODEL; TIME;

D O I：

10.1126/science.1244056

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In many species, spatial navigation is supported by a network of place cells that exhibit increased firing whenever an animal is in a certain region of an environment. Does this neural representation of location form part of the spatiotemporal context into which episodic memories are encoded? We recorded medial temporal lobe neuronal activity as epilepsy patients performed a hybrid spatial and episodic memory task. We identified place-responsive cells active during virtual navigation and then asked whether the same cells activated during the subsequent recall of navigation-related memories without actual navigation. Place-responsive cell activity was reinstated during episodic memory retrieval. Neuronal firing during the retrieval of each memory was similar to the activity that represented the locations in the environment where the memory was initially encoded.

引用

页码：1111 / 1114

页数：4

共 29 条

[1]

[Anonymous], 1983, Canadian Psychology

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