Cardioprotective Effects of Total Flavonoids Extracted from Xinjiang Sprig Rosa rugosa against Acute Ischemia/Reperfusion-Induced Myocardial Injury in Isolated Rat Heart

被引：15

作者：

Hou, Xuejiao ^{[1
]}

Han, Jichun ^{[1
]}

Yuan, Changsheng ^{[1
]}

Ren, Huanhuan ^{[1
]}

Zhang, Ya ^{[1
]}

Zhang, Tao ^{[1
]}

Xu, Lixia ^{[1
]}

Zheng, Qiusheng ^{[1
]}

Chen, Wen ^{[1
]}

机构：

[1] Shihezi Univ, Sch Pharm, Key Lab Xinjiang Endem Phytomed Resources, Minist Educ, Shihezi 832002, Peoples R China

来源：

CARDIOVASCULAR TOXICOLOGY | 2016年 / 16卷 / 01期

关键词：

Xinjiang sprig Rosa rugosa; Total flavonoid; Antioxidant; Antiapoptotic; Anti-inflammatory; Cardioprotective activity; Ischemia/reperfusion; ISCHEMIA-REPERFUSION INJURY; ANTIOXIDANT PROPERTIES; PROTECTION; INHIBITION; MECHANISMS; CAPACITY; CELLS;

D O I：

10.1007/s12012-015-9308-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study evaluated the antioxidative and cardioprotective effects of total flavonoids extracted from Xinjiang sprig Rosa rugosa on ischemia/reperfusion (I/R) injury using an isolated Langendorff rat heart model. The possible mechanism of Xinjiang sprig rose total flavonoid (XSRTF) against I/R injury was also studied. XSRTF (5, 10, and 20 A mu g/mL) dissolved in Krebs-Henseleit buffer was administered to isolated rat heart. The XSRTF showed remarkable scavenging effects against 1,1-diphenyl-2-picrylhydrazyl, hydroxyl, and superoxide anion radicals in vitro. XSRTF pretreatment improved the heart rate, increased LVDP, and decreased CK and LDH levels in coronary flow. This pretreatment also increased SOD activity and GSH/GSSG ratio but decreased MDA, TNF-alpha, and CRP levels and IL-8 and IL-6 activities. The infarct size and cell apoptosis in the hearts from the XSRTF-treated group were lower than those in the hearts from the I/R group. Therefore, the cardioprotective effects of XSRTF may be attributed to its antioxidant, antiapoptotic, and anti-inflammatory activities.

引用

页码：54 / 66

页数：13

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