Furanocoumarins with affinity to brain benzodiazepine receptors in vitro

被引：102

作者：

Bergendorff, O

Dekermendjian, K

Nielsen, M

Shan, RD

Witt, R

Ai, JL

Sterner, O

机构：

[1] LUND UNIV,DIV ORGAN CHEM 2,S-22100 LUND,SWEDEN

[2] SCT HANS MENTAL HOSP,DEPT BIOCHEM,DK-4000 ROSKILDE,DENMARK

来源：

PHYTOCHEMISTRY | 1997年 / 44卷 / 06期

关键词：

Angelica dahurica; Umbelliferae; roots; furanocoumarins; phellopterin; benzodiazepine receptor;

D O I：

10.1016/S0031-9422(96)00703-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 mu M) inhibits the binding of [H-3]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active. Copyright (C) 1997 Elsevier Science Ltd.

引用

页码：1121 / 1124

页数：4

共 11 条

[1]

BABUDRI N, 1986, J ENVIRON PATHOL TOX, V19, P123

[2]

DALLACQUA F, 1984, NATL CANC I MONOGRAP, V1818, P55

[3] THE PHARMACOLOGY, METABOLISM, ANALYSIS, AND APPLICATIONS OF COUMARIN AND COUMARIN-RELATED COMPOUNDS [J].