Prospective Evaluation of Ghrelin and Des-Acyl Ghrelin Plasma Levels in Children with Newly Diagnosed Epilepsy: Evidence for Reduced Ghrelin-to-Des-Acyl Ghrelin Ratio in Generalized Epilepsies

被引：10

作者：

Costa, Anna-Maria ^{[1
]}

Lo Barco, Tommaso ^{[2
,3
]}

Spezia, Elisabetta ^{[4
]}

Conti, Valerio ^{[5
]}

Roli, Laura ^{[6
]}

Marini, Lorenza ^{[5
]}

Minghetti, Sara ^{[5
]}

Caramaschi, Elisa ^{[4
]}

Pietrangelo, Laura ^{[5
]}

Pecoraro, Luca ^{[7
]}

D'Achille, Fabio ^{[6
]}

Accorsi, Paola ^{[7
]}

Trenti, Tommaso ^{[6
]}

Melani, Federico ^{[5
]}

Marini, Carla ^{[5
]}

Guerrini, Renzo ^{[5
]}

Darra, Francesca ^{[2
]}

Bergonzini, Patrizia ^{[4
]}

Biagini, Giuseppe ^{[1
]}

机构：

[1] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Via G Campi 287, I-41125 Modena, Italy

[2] Univ Verona, Dept Surg Sci Dent Gynecol & Pediat, Child Neuropsychiat, I-37126 Verona, Italy

[3] Univ Modena & Reggio Emilia, PhD Sch Clin & Expt Med CEM, Via G Campi 287, I-41125 Modena, Italy

[4] Univ Hosp Modena, Dept Mother & Child, Pediat Neurol Unit, I-41125 Modena, Italy

[5] A Meyer Childrens Hosp, Pediat Neurol Neurogenet & Neurobiol Unit & Labs, I-50139 Florence, Italy

[6] Azienda USL, Dept Lab Med & Pathol, I-41126 Modena, Italy

[7] ASST Mantua, Paediat Clin, I-46100 Mantua, Italy

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2022年 / 12卷 / 04期

关键词：

antiseizure medications; children; epilepsy; generalized epilepsy; ghrelin; plasma; NEUROPEPTIDE-Y; SERUM GHRELIN; BODY-WEIGHT; LEPTIN; OBESTATIN; GROWTH; SALIVA;

D O I：

10.3390/jpm12040527

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Children with epilepsy and identified as responders to antiseizure medications (ASMs) were found to present markedly higher ghrelin plasma levels when compared to drug-resistant patients. However, it was undetermined if this phenotype could be influenced by the ASMs. Here, we prospectively investigated total ghrelin and des-acyl ghrelin (DAG) plasma levels by enzyme-linked immunosorbent assay before and after ASM administration. Inclusion criteria were: (i) subject with a suspicion of epilepsy; (ii) age ranging from 0 to 16 years; and (iii) informed consent signed by parents or caregivers. Exclusion criteria were acute or chronic metabolic disorders with occasional convulsions but without epilepsy. Fifty patients were followed over a period of one year in Italian neuropediatric centers. Apart from a few exceptions, the majority of children were responsive to ASMs. No differences were found in total ghrelin and DAG levels before and after the treatment, but total ghrelin levels were significantly lower in children with generalized epilepsy compared to those with combined focal and generalized epilepsy. Moreover, the ghrelin-to-DAG ratio was also markedly lower in generalized epilepsies compared to all the other types of epilepsy. Finally, ghrelin was unchanged by ASMs, including the first (e.g., carbamazepine), second (levetiracetam), and third (lacosamide) generation of anticonvulsants.

引用

页数：13

共 45 条

[1] Nesfatin-1 and ghrelin levels in serum and saliva of epileptic patients: hormonal changes can have a major effect on seizure disorders [J].