Immunology of COVID-19

被引:20
作者
Brussow, Harald [1 ]
机构
[1] Katholieke Univ Leuven, Lab Gene Technol, Dept Biosyst, Leuven, Belgium
关键词
IMMUNITY; REVEAL; MILD;
D O I
10.1111/1462-2920.15302
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The immune response to SARS-CoV-2 reveals a delicate balance between protective effects and harmful pathological reactions and can possibly explain the highly variable disease manifestations in subjects infected with this novel coronavirus. A better understanding of the anti-viral immune response is not only critical for vaccine development but might also provide targets for pharmaceutical and immunological treatment options. Recent research literature on immune aspects of COVID-19 is summarized in this review with an outlook how bats have evolved to live with these viral infections.
引用
收藏
页码:4895 / 4908
页数:14
相关论文
共 57 条
[51]   Evasion of Type I Interferon by SARS-CoV-2 [J].
Xia, Hongjie ;
Cao, Zengguo ;
Xie, Xuping ;
Zhang, Xianwen ;
Chen, John Yun-Chung ;
Wang, Hualei ;
Menachery, Vineet D. ;
Rajsbaum, Ricardo ;
Shi, Pei-Yong .
CELL REPORTS, 2020, 33 (01)
[52]   Loss of Anti-SARS-CoV-2 Antibodies in Mild Covid-19 [J].
Boelke, Edwin ;
Matuschek, Christiane ;
Fischer, Johannes C. .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (17) :1694-1695
[53]   Structural basis of a shared antibody response to SARS-CoV-2 [J].
Yuan, Meng ;
Liu, Hejun ;
Wu, Nicholas C. ;
Lee, Chang-Chun D. ;
Zhu, Xueyong ;
Zhao, Fangzhu ;
Huang, Deli ;
Yu, Wenli ;
Hua, Yuanzi ;
Tien, Henry ;
Rogers, Thomas F. ;
Landais, Elise ;
Sok, Devin ;
Jardine, Joseph G. ;
Burton, Dennis R. ;
Wilson, Ian A. .
SCIENCE, 2020, 369 (6507) :1119-+
[54]   The major genetic risk factor for severe COVID-19 is inherited from Neanderthals [J].
Zeberg, Hugo ;
Paabo, Svante .
NATURE, 2020, 587 (7835) :610-+
[55]   Longitudinal Change of Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies in Patients with Coronavirus Disease 2019 [J].
Zhang, Guoxin ;
Nie, Shuke ;
Zhang, Zhaohui ;
Zhang, Zhentao .
JOURNAL OF INFECTIOUS DISEASES, 2020, 222 (02) :183-188
[56]   Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 [J].
Zhang, Qian ;
Bastard, Paul ;
Liu, Zhiyong ;
Le Pen, Jeremie ;
Moncada-Velez, Marcela ;
Chen, Jie ;
Ogishi, Masato ;
Sabli, Ira K. D. ;
Hodeib, Stephanie ;
Korol, Cecilia ;
Rosain, Jeremie ;
Bilguvar, Kaya ;
Ye, Junqiang ;
Bolze, Alexandre ;
Bigio, Benedetta ;
Yang, Rui ;
Arias, Andres Augusto ;
Zhou, Qinhua ;
Zhang, Yu ;
Onodi, Fanny ;
Korniotis, Sarantis ;
Karpf, Lea ;
Philippot, Quentin ;
Chbihi, Marwa ;
Bonnet-Madin, Lucie ;
Dorgham, Karim ;
Smith, Nikaia ;
Schneider, William M. ;
Razooky, Brandon S. ;
Hoffmann, Hans-Heinrich ;
Michailidis, Eleftherios ;
Moens, Leen ;
Han, Ji Eun ;
Lorenzo, Lazaro ;
Bizien, Lucy ;
Meade, Philip ;
Neehus, Anna-Lena ;
Ugurbil, Aileen Camille ;
Corneau, Aurelien ;
Kerner, Gaspard ;
Zhang, Peng ;
Rapaport, Franck ;
Seeleuthner, Yoann ;
Manry, Jeremy ;
Masson, Cecile ;
Schmitt, Yohann ;
Schlueter, Agatha ;
Le Voyer, Tom ;
Khan, Taushif ;
Li, Juan .
SCIENCE, 2020, 370 (6515)
[57]   Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019 [J].
Zhao, Juanjuan ;
Yuan, Quan ;
Wang, Haiyan ;
Liu, Wei ;
Liao, Xuejiao ;
Su, Yingying ;
Wang, Xin ;
Yuan, Jing ;
Li, Tingdong ;
Li, Jinxiu ;
Qian, Shen ;
Hong, Congming ;
Wang, Fuxiang ;
Liu, Yingxia ;
Wang, Zhaoqin ;
He, Qing ;
Li, Zhiyong ;
He, Bin ;
Zhang, Tianying ;
Fu, Yang ;
Ge, Shengxiang ;
Liu, Lei ;
Zhang, Jun ;
Xia, Ningshao ;
Zhang, Zheng .
CLINICAL INFECTIOUS DISEASES, 2020, 71 (16) :2027-2034