One-Pot Synthesis of Benzo[4,5]imidazo[1,2-a]quinazoline Derivatives via Facile Transition-Metal-Free Tandem Process

被引：31
作者：
Fang, Shuai [1 ]
Niu, Xiaoyi [1 ]
Yang, Bingchuan [1 ]
Li, Yanqiu [1 ]
Si, Xiaomeng [1 ]
Feng, Lei [1 ]
Ma, Chen [1 ,2 ,3 ]
机构：
[1] Shandong Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Special Funct Aggregated Mat, Jinan 250100, Peoples R China
[2] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[3] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
ACS COMBINATORIAL SCIENCE | 2014年 / 16卷 / 07期
基金：
美国国家科学基金会;
关键词：
one-pot synthesis; transition metal-free; benzo(4,5]imidazo[1,2-a]quinazoline derivatives; fluorescence property; ANTIMICROBIAL ACTIVITY; PYRIMIDINE;
D O I：
10.1021/co500001u
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A one-pot transition metal-free method for synthesizing benzo[4,5]imidazo[1,2-a]quinazoline and imidazo-[1,2-a]quinazoline derivatives has been developed. The approach is widely applicable to 2-fluoro-, 2-chloro-, 2-bromo- and 2-nitro-substituted aryl aldehyde and ketone substrates. The fluorescence properties of target compounds were studied.
引用
收藏
页码：328 / 332
页数：5
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