Monte Carlo study of the selectivity of calcium channels: improved geometrical model

被引：46
作者：
Boda, D
Henderson, D [1 ]
Busath, DD
机构：
[1] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA
[2] Univ Veszprem, Dept Chem Phys, H-8201 Veszprem, Hungary
来源：
MOLECULAR PHYSICS | 2002年 / 100卷 / 14期
基金：
美国国家卫生研究院; 匈牙利科学研究基金会; 美国国家科学基金会;
关键词：
D O I：
10.1080/00268970210125304
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
An extended model of a calcium channel is described involving a channel with a finite length. With this new geometry the channel is still selective but less so than in an infinite cylinder geometry (Boda, D., Busath, D. D., Henderson, D., and Sokolowski, S., 2000, J. phys. Chem. B, 104, 8903). The selectivity of the channel depends on the width and length of the channel filter but is not significantly affected by changes in the size of the entry vestibules. Interestingly, changes in the size of the entry vestibules do affect the details of the concentration profiles of some of the ions.
引用
收藏
页码：2361 / 2368
页数：8
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