ANALYSIS OF COMPARISON OF EFFECTS OF METHOTREXATE WITH THE COMBINATION OF METHYLPREDNISOLONE IN SPINAL CORD INJURY

Introduction: The incidence of spinal cord injury (SCI) caused by many events, including traffic accidents, mining and construction accidents, seismic and natural disasters, has tended to rise year on year. The pathology of SCI usually includes primary injury and secondary injury. Aims and objectives: The basic aim of the study is to analyze the comparison of effects of methotrexate with the combination of methylprednisolone in spinal cord injury. Material and methods: This cross sectional study was conducted in Fatima Memorial Hospital Lahore during March 2018 to November 2018. A total of 100 patients who were suffering from spinal injury due to any reason were included in this study. After analysis dose of drug according to schedule was given to the all patients. For biochemical analysis 5cc blood sample was taken from vein and sample were processed with phosphate buffer saline using homogenizer. Thiobarbituric acid reactive substances were measured according to the method of Mihara et al. Myeloperoxidation (MPO) activity of the tissue sample was measured according to the method of Suzuki et al. Results: The variations between the mean values of MPO levels were significant according to the ANOVA and t-test. There were significant difference between control groups and treated groups. The data shows that the group of patients which was treated with both MTX and MP as a combine effect shows more close values to the control. But the separate effect shows somehow different values as compared to control