Dimethyl Acetylenedicarboxylate: A Versatile Tool in Organic Synthesis

被引：60

作者：

Neochoritis, Constantinos G. ^{[1
]}

Zarganes-Tzitzikas, Tryfon ^{[1
]}

Stephanidou-Stephanatou, Julia ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Organ Chem Lab, Dept Chem, Thessaloniki 54124, Macedonia

来源：

SYNTHESIS-STUTTGART | 2014年 / 46卷 / 05期

关键词：

DMAD; dimethyl acetylenedicarboxylate; Michael reactions; cycloadditions; multicomponent reactions; ONE-POT SYNTHESIS; DIELS-ALDER REACTIONS; BRIDGED 10-MEMBERED RINGS; STABLE PHOSPHORUS YLIDES; ELECTRON-POOR ACETYLENES; N-HETEROCYCLIC CARBENES; BOND-FORMING REACTIONS; SOLVENT-FREE SYNTHESIS; 3 COMPONENT REACTION; MULTICOMPONENT REACTIONS;

D O I：

10.1055/s-0033-1340615

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This review presents the recent progress in the chemistry of dimethyl acetylenedicarboxylate (DMAD). The interest in and applications of this powerful reagent with more than 135 years of history have greatly increased in the last 10 years, further proving its versatility. Undoubtedly, DMAD can be a multi-tool in the quest of molecular complexity and diversity. The extreme structural diversity of the products described in this review illustrates the powerful potential of DMAD as a building block in organic synthesis.

引用

页码：537 / 585

页数：49

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