A First Synthesis of Bis(benzoxazole) Natural Products: Nataxazole and AJI9561 via Benzoxazole C-H Activation

被引：9

作者：

Sasmal, Swarnendu ^{[1
]}

Sen, Indira ^{[1
]}

Hall, Roger G. ^{[2
]}

Pal, Sitaram ^{[1
]}

机构：

[1] Syngenta Biosci Pvt Ltd, Santa Monica Works, Ilhas 403110, Goa, India

[2] Munchwilen AG, Syngenta Crop Protect, CH-4332 Stein, Switzerland

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 23期

关键词：

natural products; nataxazole; AJI9561; UK-1; C-H activation; CATALYZED DIRECT ARYLATION; HUMAN TOPOISOMERASE-II; STREPTOMYCES SP 517-02; SP TU 6176; CYTOTOXIC METABOLITE; BIOLOGICAL EVALUATION; COCATALYTIC SYSTEM; BOND FORMATION; UK-1; ANALOGS;

D O I：

10.1055/s-0035-1560070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Concise and efficient syntheses of nataxazole and AJI9561 have been accomplished. We also demonstrate a convenient route to obtain the related natural product UK-1. The key step involves C-H activation of a benzoxazole in the presence of ortho-iodoanilides using a copper(I) iodide/Xantphos/palladium(II) acetate system.

引用

页码：3711 / 3716

页数：6

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