The anti-inflammatory activity of bentonites

被引：9

作者：

Cervini-Silva, Javiera ^{[1
,2
,3
]}

Antonio-Nieto-Camacho ^{[4
]}

Kaufhold, Stephan ^{[5
]}

Ufer, Kristian ^{[5
]}

Ronquillo de Jesus, Elba ^{[1
]}

机构：

[1] Univ Autonoma Metropolitana, Dept Proc & Tecnol, Mexico City 05348, DF, Mexico

[2] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Earth Sci, Berkeley, CA 94720 USA

[3] NASA, Astrobiol Inst, Washington, DC USA

[4] Univ Nacl Utonoma Mexico, Inst Quim, Lab Pruebas Biol, Mexico City, DF, Mexico

[5] BGR Bundesansalt Geowissensch & Rohstoffe, D-30655 Hannover, Germany

来源：

APPLIED CLAY SCIENCE | 2015年 / 118卷

关键词：

Edema inhibition; Smectites; IN-VITRO BIOCOMPATIBILITY; WATER; ANTIBACTERIAL; ALLOPHANE; CLAYS; QUANTIFICATION; SUSPENSIONS; CAPACITY; ECUADOR; CEC;

D O I：

10.1016/j.clay.2015.08.039

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Bentonites, naturally occurring clays, are produced industrially because of their adsorbent capacity but little is known about their effects on human health. This manuscript reports on the anti-inflammatory activity of bentonites. Bentonites collected from India (Bent-India), Hungary (Bent-Hungary), Argentina (Bent-Argentina), and Indonesia (Bent-Indonesia) were studied. All four bentonites were tested for anti-inflammatory activity using the mouse ear edema and the 12-O-tetradecanoylphorbol-13-acetate (TPA) method. Bentonites inhibited edema after 4 h (El %), regardless of composition. A direct comparison between El and surface area values showed that Bent-Argentina was four times more active than the other bentonites, with infiltration-preferred in the former case. We attributed the inhibition of edema by bentonites to clay swelling, causing physical occlusion thereby limiting the movement of leukocyte cells towards the inflammation site. Expandability over changes in mineral composition underpinned inhibition of edema by bentonites, while evidence lacked to support chemical-transfer mechanism(s). (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：56 / 60

页数：5

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