ADSC Therapy in Neurodegenerative Disorders

被引：43

作者：

Chan, Tzu-Min ^{[1
,2
]}

Chen, Julia Yi-Ru ^{[3
]}

Ho, Li-Ing ^{[4
]}

Lin, Hui-Ping ^{[5
]}

Hsueh, Kuo-Wei ^{[6
]}

Liu, Demeral David ^{[7
]}

Chen, Yi-Hung ^{[8
]}

Hsieh, An-Cheng ^{[1
]}

Tsai, Nu-Man ^{[9
,10
]}

Hueng, Dueng-Yuan ^{[11
]}

Tsai, Sheng-Tzeng ^{[12
]}

Chou, Pei-Wen ^{[2
,3
]}

Lin, Shinn-Zong ^{[1
,13
,14
,15
]}

Harn, Horng-Jyh ^{[16
,17
]}

机构：

[1] China Med Univ Hosp, Ctr Neuropsychiat, Taichung, Taiwan

[2] Everfront Biotech Inc, New Taipei City, Taiwan

[3] Guang Li Biomed Inc, New Taipei City, Taiwan

[4] Taipei Vet Gen Hosp, Dept Resp Therapy, Taipei, Taiwan

[5] Natl Hlth Res Inst, Inst Cellular & Syst Med, Miaoli, Taiwan

[6] China Med Univ, PhD Program Aging, Taichung, Taiwan

[7] China Med Univ, Beigang Hosp, Dept Dent, Beigang, Taiwan

[8] China Med Univ, Grad Inst Acupuncture Sci, Taichung, Taiwan

[9] Chung Shan Med Univ, Sch Med Lab & Biotechnol, Taichung, Taiwan

[10] Chung Shan Med Univ Hosp, Dept Pathol & Lab, Taichung, Taiwan

[11] Triserv Gen Hosp, Natl Def Med Ctr, Dept Neurol Surg, Taipei, Taiwan

[12] Tzu Chi Univ, Dept Neurosurg, Tzu Chi Gen Hosp, Hualien, Taiwan

[13] China Med Univ, Beigang Hosp, Dept Neurosurg, Yunlin, Taiwan

[14] China Med Univ, Tainan Municipal An Nan Hosp, Dept Neurosurg, Tainan, Taiwan

[15] China Med Univ, Grad Inst Immunol, Taichung, Taiwan

[16] China Med Univ, Dept Med, Taichung, Taiwan

[17] China Med Univ Hosp, Dept Pathol, Taichung, Taiwan

来源：

CELL TRANSPLANTATION | 2014年 / 23卷 / 4-5期

关键词：

Neurodegenerative disorders; Adipose tissue-derived stem cells (ADSCs); Amyotrophic lateral sclerosis; Parkinson's disease; Alzheimer's disease; Huntington's disease; Autoimmune encephalomyelitis; Krabbe disease; Niemann-Pick disease; Friedreich's ataxia; AMYOTROPHIC-LATERAL-SCLEROSIS; MESENCHYMAL STEM-CELLS; HUMAN ADIPOSE-TISSUE; ALZHEIMERS-DISEASE; MOUSE MODEL; PARKINSONS-DISEASE; OXIDATIVE STRESS; TRANSPLANTATION THERAPY; HUNTINGTONS-DISEASE; PROGENITOR CELLS;

D O I：

10.3727/096368914X678445

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Neurodegenerative disorders, chronic diseases that can severely affect the patient's daily life, include amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, and Huntington's diseases. However, these diseases all have the common characteristic that they are due to degenerative irreversibility, and thus no efficient drugs or therapy methods can mitigate symptoms completely. Stem cell therapy, such as adipose tissue-derived stem cells (ADSCs), is a promising treatment for incurable disorders. In this review, we summarized the previous studies using ADSCs to treat neurodegenerative disorders, as well as their therapeutic mechanisms. We also suggested possible expectations for future human clinical trials involving minimized intracerebroventricular combined with intravenous administration, using different cell lineages to finish complementary therapy as well as change the extracellular matrix to create a homing niche. Depending on successful experiments in relevant neurodegenerative disorders models, this could form the theoretical basis for future human clinical trials.

引用

页码：549 / 557

页数：9

共 88 条

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