New acyclic diterpenoids from the fruits of Aphanamixis grandifolia and structure revision of nemoralisin B

被引：10

作者：

Zhang, Hai-Yuan ^{[1
,2
]}

Yuan, Chun-Mao ^{[1
]}

Cao, Ming-Ming ^{[1
]}

Li, Xiao-Hui ^{[1
]}

Li, Shun-Lin ^{[1
]}

Zhang, Yu ^{[1
]}

Hao, Xiao-Jiang ^{[1
]}

He, Hong-Ping ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

[3] Yunnan Univ TCM, Fac Pharm, Kunming 650500, Yunnan, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2014年 / 8卷

关键词：

Aphanamixis grandifolia; Meliaceae; Acyclic diterpenoids; Structure revision; LIMONOIDS; TRITERPENOIDS; RING;

D O I：

10.1016/j.phytol.2014.02.005

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new acyclic diterpenoids (i.e., nemoralisin B (1) and nemoralisins H-J (2-4)) along with three known acyclic diterpenoids (i.e., nemoralisin, nemoralisin A, and nemoralisin D) were isolated from the fruits of Aphanamixis grandifolia. Their structures were determined by extensive spectroscopic studies using NMR spectroscopy and mass spectrometry. In addition, the structure of nemoralisin B has been revised from the previously reported a,beta-unsaturated delta-lactone structure to an a,beta-unsaturated glactone one. Nemoralisin J (4) exhibited moderate inhibitory activity against lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells with an IC50 value of 9.96 mu M. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：81 / 85

页数：5

共 20 条

[1] CD OF ALPHA-BETA-UNSATURATED LACTONES [J].