A Novel Microwave-Assisted Green Synthesis of Condensed 2-Substituted-pyrimidin-4(3H)-ones Under Solvent-Free Conditions

被引：9

作者：

Jain, Kishor S. ^{[1
]}

Bariwal, Jitender B. ^{[1
]}

Phouidar, Manisha S. ^{[1
]}

Nagras, Madhuri A. ^{[1
]}

Amrutkar, Rakesh D. ^{[1
]}

Munde, Manoj K. ^{[1
]}

Tamboli, Riyaj S. ^{[1
]}

Khedkar, Samrat A. ^{[1
]}

Khiste, Rahul H. ^{[1
]}

Vidyasagar, Nikhil C. ^{[1
]}

Dabholkar, Vinit V. ^{[1
]}

Kathiravan, M. K. ^{[1
]}

机构：

[1] Sinhgad Coll Pharm, Dept Pharmaceut Chem, Pune 411041, Maharashtra, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 46卷 / 02期

关键词：

ACIDIC CONDITIONS; NITRILES; PYRIMIDINES; AMINONITRILES;

D O I：

10.1002/jhet.30

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rapid microwave-assisted green chemical synthesis of condensed 2-substituted-pyrimidin-4(3H)ones 3, 4, and 5 involving the condensation of a variety of nitriles with o-aminoesters of thiophene 2a-e, benzene 2f, dimethoxybenzene 2g and quinazolinone 2h in the presence of catalytic amount of HCl alone or with the Lewis acid AICl(3) under solvent-free conditions, is described for the first time. This novel and clean one-pot methodology, which is characterized by very short reaction times and easy workup procedures, can be exploited to generate a diverse library of condensed pyrimidine heterocycles.

引用

页码：178 / 185

页数：8

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