Specific Mutations in APC, but Not Alterations in DNA Damage Response, Associate With Outcomes of Patients With Metastatic Colorectal Cancer

被引：34
|
作者：
Mondaca, Sebastian [1 ]
Walch, Henry [2 ]
Nandakumar, Subhiksha [2 ]
Chatila, Walid K. [2 ,3 ]
Schultz, Nikolaus [2 ,4 ,5 ]
Yaeger, Rona [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
[2] Mem Sloan Kettering Canc Ctr, Marie Josee & Henry R Kravis Ctr Mol Oncol, New York, NY 10065 USA
[3] Weill Cornell Med Coll, Triinst Program Computat Biol & Med, New York, NY USA
[4] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10065 USA
[5] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA
来源：
GASTROENTEROLOGY | 2020年 / 159卷 / 05期
关键词：
APC; Colorectal Cancer; DNA Damage Response;
D O I：
10.1053/j.gastro.2020.07.041
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
引用
收藏
页码：1975 / +
页数：8
相关论文
共 50 条
  • [41] DNA damage response and repair gene mutations predict clinical outcomes in biliary tract cancer
    Tan, Sirui
    Feng, Mingyang
    Zhou, Nan
    Zhang, Shunyu
    Yi, Cheng
    Gou, Hongfeng
    CANCER, 2025, 131 (03)
  • [42] Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer
    Souglakos, J.
    Philips, J.
    Wang, R.
    Marwah, S.
    Silver, M.
    Tzardi, M.
    Silver, J.
    Ogino, S.
    Hooshmand, S.
    Kwak, E.
    Freed, E.
    Meyerhardt, J. A.
    Saridaki, Z.
    Georgoulias, V.
    Finkelstein, D.
    Fuchs, C. S.
    Kulke, M. H.
    Shivdasani, R. A.
    BRITISH JOURNAL OF CANCER, 2009, 101 (03) : 465 - 472
  • [43] Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer
    J Souglakos
    J Philips
    R Wang
    S Marwah
    M Silver
    M Tzardi
    J Silver
    S Ogino
    S Hooshmand
    E Kwak
    E Freed
    J A Meyerhardt
    Z Saridaki
    V Georgoulias
    D Finkelstein
    C S Fuchs
    M H Kulke
    R A Shivdasani
    British Journal of Cancer, 2009, 101 : 465 - 472
  • [44] Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer
    Tie, J.
    Kinde, I.
    Wang, Y.
    Wong, H. L.
    Roebert, J.
    Christie, M.
    Tacey, M.
    Wong, R.
    Singh, M.
    Karapetis, C. S.
    Desai, J.
    Tran, B.
    Strausberg, R. L.
    Diaz, L. A., Jr.
    Papadopoulos, N.
    Kinzler, K. W.
    Vogelstein, B.
    Gibbs, P.
    ANNALS OF ONCOLOGY, 2015, 26 (08) : 1715 - 1722
  • [45] Prognostic impact of ATM mutations in patients with metastatic colorectal cancer
    Giovanni Randon
    Giovanni Fucà
    Daniele Rossini
    Alessandra Raimondi
    Filippo Pagani
    Federica Perrone
    Elena Tamborini
    Adele Busico
    Giorgia Peverelli
    Federica Morano
    Monica Niger
    Maria Antista
    Salvatore Corallo
    Serena Saggio
    Beatrice Borelli
    Gemma Zucchelli
    Massimo Milione
    Giancarlo Pruneri
    Maria Di Bartolomeo
    Alfredo Falcone
    Filippo de Braud
    Chiara Cremolini
    Filippo Pietrantonio
    Scientific Reports, 9
  • [46] Prognostic impact of ATM mutations in patients with metastatic colorectal cancer
    Randon, Giovanni
    Fuca, Giovanni
    Rossini, Daniele
    Raimondi, Alessandra
    Pagani, Filippo
    Perrone, Federica
    Tamborini, Elena
    Busico, Adele
    Peverelli, Giorgia
    Morano, Federica
    Niger, Monica
    Antista, Maria
    Corallo, Salvatore
    Saggio, Serena
    Borelli, Beatrice
    Zucchelli, Gemma
    Milione, Massimo
    Pruneri, Giancarlo
    Di Bartolomeo, Maria
    Falcone, Alfredo
    de Braud, Filippo
    Cremolini, Chiara
    Pietrantonio, Filippo
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [47] Treatment outcomes for patients (Pts) with metastatic castration resistant prostate cancer (mCRPC) pts and DNA damage repair gene mutations.
    Yip, Steven
    Angeles, Arkhjamil
    Beigi, Arshia
    Warner, Evan W.
    Khalaf, Daniel
    Sunderland, Katherine
    Vandekerkhove, Gillian Rae
    Annala, Matti
    Schrader, Kasmintan A.
    Wyatt, Alexander William
    Chi, Kim N.
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
  • [48] Mutations in DNA damage response genes and breast cancer susceptibility
    Clarke R.B.
    Breast Cancer Research, 4 (6) : 253 - 254
  • [49] Evaluation of Emergent Mutations in Circulating Cell-Free DNA and Clinical Outcomes in Patients with Metastatic Colorectal Cancer Treated with Panitumumab in the ASPECCT Study
    Peeters, Marc
    Price, Timothy
    Boedigheimer, Michael
    Kim, Tae Won
    Ruff, Paul
    Gibbs, Peter
    Thomas, Anne
    Demonty, Gaston
    Hool, Kristina
    Ang, Agnes
    CLINICAL CANCER RESEARCH, 2019, 25 (04) : 1216 - 1225
  • [50] Analysis of DNA Damage Response Gene Alterations and Its Association With Tumor Mutational Burden in Asian Colorectal Cancer
    Bekaii-Saab, Tanios S.
    Haller, Daniel G.
    ONCOLOGY-NEW YORK, 2020, 34 (11): : 472 - 473
12345