Preparation and Properties of Molecularly Imprinted Nanofiber Memberanes Towards Enrofloxacin

Enrofloxacin(ENRO) molecular imprinted polymers(MIPs) obtained via precipitation polymerization were added to the polyvinyl alcohol (PVA) aqueous solution. Then electrospinning technique was employed to prepare ENRO molecularly imprinted nanofiber membranes (MINFMs). We investigated the effects of concentration of PVA solution, applied voltage, and the distance between the needle and collector on the diameter and morphology of the nanofiber membrane via scanning electron microscope (SEM) measurement. The swelling ratio, void ratio, adsorption property, and adsorption selectivity of membrane were also studied. The optimal electrospinning process was carried out at environmental temperature of 25 degrees C and relative humidity of 40%-50%, with PVA concentration of 7.0% (mass fraction), spinning voltage of 15 kV, and the distance between the needle and collector of 25 cm. Under such conditions, the fibers in MINFMs were uniform with diameters of about 180 nm. The swelling rate and void ratio of the as-prepared MINFMs were 136.76% and 33.42%, respectively, which were more than those of non-imprinted nanofiber membranes (NINFMs). The dynamic adsorption experiments of MINFMs showed that the adsorption reaction reached balance after 300 min. Analysis of the Scatchard plot revealed that the binding sites of MINFMs to ENRO were equal class under the studied concentration range, the dissociation constant (K-d) and apparent maximum adsorption, quantity (Q(max)) of MINFMs were 505.817 mg/L and 3.862 mg/g, respectively. The specific absorption capacity of, MINFMs to ENRO was higher than those of ciprofloxacin(CIP) and ofloxacin(OFL).