Antibody-secreting plasma cells persist for decades in human intestine

被引：158

作者：

Landsverk, Ole J. B. ^{[1
]}

Snir, Omri ^{[2
]}

Casado, Raquel Bartolome ^{[1
]}

Richter, Lisa ^{[1
]}

Mold, Jeff E. ^{[6
]}

Reu, Pedro ^{[6
,7
]}

Horneland, Rune ^{[8
]}

Paulsen, Vemund ^{[8
]}

Yaqub, Sheraz ^{[9
]}

Aandahl, Einar Martin ^{[5
,8
]}

Oyen, Ole M. ^{[8
]}

Thorarensen, Hildur Sif ^{[10
]}

Salehpour, Mehran ^{[11
]}

Possnert, Goran ^{[11
]}

Frisen, Jonas ^{[6
]}

Sollid, Ludvig M. ^{[3
,4
]}

Baekkevold, Espen S. ^{[1
]}

Jahnsen, Frode L. ^{[1
]}

机构：

[1] Rigshosp, Oslo Univ Hosp, Ctr Immune Regulat, Dept Pathol, N-0372 Oslo, Norway

[2] Rigshosp, Oslo Univ Hosp, Dept Immunol, Ctr Immune Regulat, N-0372 Oslo, Norway

[3] Rigshosp, Oslo Univ Hosp, Dept Immunol, Ctr Immune Regulat, N-0372 Oslo, Norway

[4] Rigshosp, Oslo Univ Hosp, KG Jebsen Coeliac Dis Res Ctr, N-0372 Oslo, Norway

[5] Rigshosp, Oslo Univ Hosp, Ctr Mol Med Norway, Nord European Mol Biol Lab Partnership, N-0372 Oslo, Norway

[6] Karolinska Inst, Dept Cell & Mol Biol, S-17177 Stockholm, Sweden

[7] Univ Coimbra, Ctr Neurosci & Cell Biol, P-3000213 Coimbra, Portugal

[8] Rigshosp, Oslo Univ Hosp, Dept Transplantat Med, N-0372 Oslo, Norway

[9] Rigshosp, Oslo Univ Hosp, Dept Gastrointestinal Surg, N-0372 Oslo, Norway

[10] Univ Oslo, Dept Informat, N-0313 Oslo, Norway

[11] Uppsala Univ, Dept Phys & Astron, Ion Phys, S-75236 Uppsala, Sweden

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2017年 / 214卷 / 02期

基金：

瑞典研究理事会;

关键词：

ACCELERATOR MASS-SPECTROMETRY; HUMAN BONE-MARROW; IMMUNE-RESPONSES; IGA; IMMUNOGLOBULIN; TRANSPLANTATION; REPERTOIRES; EXPRESSION; GENERATION; SURVIVAL;

D O I：

10.1084/jem.20161590

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by retrospective cell birth dating measuring carbon-14 in genomic DNA. We identified three distinct PC subsets: a CD19(+) PC subset was dynamically exchanged, whereas of two CD19(-) PC subsets, CD45(+) PCs exhibited little and CD45(-) PCs no replacement and had a median age of 11 and 22 yr, respectively. Accumulation of CD45(-) PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19(-) PC subsets support selection and maintenance of protective PCs for life in human intestine.

引用

页码：309 / 317

页数：9

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