Spatially Fractionated Radiotherapy (GRID) Prior to Standard Neoadjuvant Conventionally Fractionated Radiotherapy for Bulky, High-Risk Soft Tissue and Osteosarcomas: Feasibility, Safety, and Promising Pathologic Response Rates

被引：29

作者：

Snider, James W. ^{[1
]}

Molitoris, Jason ^{[2
]}

Shyu, Susan ^{[2
]}

Diwanji, Tejan ^{[3
]}

Rice, Stephanie ^{[4
]}

Kowalski, Emily ^{[2
]}

Decesaris, Cristina ^{[5
]}

Remick, Jill S. ^{[5
]}

Yi, Byongyong ^{[2
]}

Zhang, Baoshe ^{[2
]}

Hall, Andrea ^{[5
]}

Hanna, Nader ^{[2
]}

Ng, Vincent Y. ^{[2
]}

Regine, William F. ^{[2
]}

机构：

[1] Univ Alabama Birmingham, Sch Med, Birmingham, AL USA

[2] Univ Maryland, Sch Med, Baltimore, MD 21201 USA

[3] Univ Miami, Sch Med, Miami, FL USA

[4] SUNY Upstate Canc Ctr, Syracuse, NY USA

[5] Univ Maryland, Med Ctr, Baltimore, MD 21201 USA

来源：

RADIATION RESEARCH | 2020年 / 194卷 / 06期

关键词：

RADIATION-THERAPY SFGRT; HIGH-GRADE; MANAGEMENT; SARCOMA; CHEMOTHERAPY; VOLUME;

D O I：

10.1667/RADE-20-00100.1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Spatially fractionated radiotherapy (GRID) has been utilized primarily in the palliative and definitive treatment of bulky tumors. Delivered in the modern era primarily with megavoltage photon therapy, this technique offers the promise of safe dose escalation with potential immunogenic, bystander and microvasculature effects that can augment a conventionally fractionated course of radiotherapy. At the University of Maryland, an institutional standard has arisen to incorporate a single fraction of GRID radiation in large (>8 cm), high-risk soft tissue and osteosarcomas prior to a standard fractionated course. Herein, we report on the excellent pathologic responses and apparent safety of this regimen in 26 consecutive patients. (C) 2020 by Radiation Research Society

引用

页码：707 / 714

页数：8

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