C-Phycocyanin as a tumour-associated macrophage-targeted photosensitiser and a vehicle of phthalocyanine for enhanced photodynamic therapy

被引：29

作者：

Wan, Dong-Hua ^{[1
]}

Zheng, Bi-Yuan ^{[1
]}

Ke, Mei-Rong ^{[1
]}

Duan, Ji-Ying ^{[1
]}

Zheng, Yun-Quan ^{[1
]}

Yeh, Chih-Kuang ^{[2
]}

Huang, Jian-Dong ^{[1
]}

机构：

[1] Fuzhou Univ, Coll Chem, State Key Lab Photocatalysis Energy & Environm, Fujian Prov Key Lab Canc Metastasis Chemoprevent, Fuzhou 350116, Peoples R China

[2] Natl Tsing Hua Univ, Dept Biomed Engn & Environm Sci, Hsinchu 30013, Taiwan

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 29期

基金：

中国国家自然科学基金;

关键词：

SPIRULINA; PURIFICATION; CANCER;

D O I：

10.1039/c6cc09541k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

C-Phycocyanin (CPC) as a tumour-associated macrophage (TAM)-targeted photosensitiser has been first proved, and used as a vehicle of zinc phthalocyanine (ZnPc) to fabricate a ZnPc-CPC conjugate, which exhibits an efficient in vitro photodynamic activity, and selectively accumulates in tumour sites probably due to the affinity to TAM.

引用

页码：4112 / 4115

页数：4

共 2 条

[1] A non-aggregated and tumour-associated macrophage-targeted photosensitiser for photodynamic therapy: a novel zinc(II) phthalocyanine containing octa-sulphonates
Li, Xing-Shu
Ke, Mei-Rong
Zhang, Miao-Fen
Tang, Qing-Qing
Zheng, Bi-Yuan
Huang, Jian-Dong
CHEMICAL COMMUNICATIONS, 2015, 51 (22) : 4704 - 4707
[2] Tumor-associated macrophage-targeted photodynamic cancer therapy using a dextran sulfate-based nano-photosensitizer
Park, Kyeongsoon
Ahn, Jae Won
Kim, Jin Hyuk
Kim, Jin Won
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 218 : 384 - 393

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