Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series

被引：177

作者：

Chagas, M. H. N. ^{[1
,2
]}

Eckeli, A. L. ^{[1
]}

Zuardi, A. W. ^{[1
,2
]}

Pena-Pereira, M. A. ^{[1
]}

Sobreira-Neto, M. A. ^{[1
]}

Sobreira, E. T. ^{[1
]}

Camilo, M. R. ^{[1
]}

Bergamaschi, M. M. ^{[1
,2
]}

Schenck, C. H. ^{[3
,4
,5
]}

Hallak, J. E. C. ^{[1
,2
]}

Tumas, V. ^{[1
]}

Crippa, J. A. S. ^{[1
,2
]}

机构：

[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Neurosci & Behav, BR-14049 Ribeirao Preto, Brazil

[2] INCT Translational Med CNPq, Sao Paulo, Brazil

[3] Hennepin Cty Med Ctr, Minnesota Reg Sleep Disorders Ctr, Minneapolis, MN 55415 USA

[4] Hennepin Cty Med Ctr, Dept Psychiat, Minneapolis, MN 55415 USA

[5] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2014年 / 39卷 / 05期

关键词：

cannabidiol; Parkinson's disease; rapid eye movement sleep behaviour disorder; CB1 CANNABINOID RECEPTOR; MODULATES SLEEP; RAT-BRAIN; IN-VITRO; LOCALIZATION; CONSTITUENT; SATIVA; CYCLE; MODEL;

D O I：

10.1111/jcpt.12179

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

What is known and objective Cannabidiol (CBD) is the main non-psychotropic component of the Cannabis sativa plant. REM sleep behaviour disorder (RBD) is a parasomnia characterized by the loss of muscle atonia during REM sleep associated with nightmares and active behaviour during dreaming. We have described the effects of CBD in RBD symptoms in patients with Parkinson's disease. Cases summary Four patients treated with CBD had prompt and substantial reduction in the frequency of RBD-related events without side effects. What is new and conclusion This case series indicates that CBD is able to control the symptoms of RBD.

引用

页码：564 / 566

页数：3

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