DSC study and calculation of metronidazole and clarithromycin thermodynamic melting parameters for individual substances and for eutectic mixture

被引：21
作者：
Agafonova, Evgeniia V. [1 ]
Moshchenskiy, Yuriy V. [1 ]
Tkachenko, Mikhail L. [2 ]
机构：
[1] Samara State Tech Univ, Samara 443100, Russia
[2] Samara State Med Univ, Samara 443099, Russia
来源：
THERMOCHIMICA ACTA | 2014年 / 580卷
关键词：
Metronidazole; Clarithromycin; Eutectic; DSC; Fusion parameters; DRUG-DELIVERY SYSTEM; HELICOBACTER-PYLORI; SOLUBILITY; BEHAVIOR;
D O I：
10.1016/j.tca.2014.01.018
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
In this study melting thermodynamic characteristics of clarithromycin and metronidazole as individual substances were investigated by DSC method. It was found that the binary system of clarithromycin and metronidazole is a system with simple eutectic. Composition, melting temperature and the heat of fusion of the eutectic were determined by calculation and experimental methods. (C) 2014 Elsevier B.V. All rights reserved.
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页码：1 / 6
页数：6
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