Aptamers: novel diagnostic and therapeutic tools for diabetes mellitus and metabolic diseases

被引：25
作者：
Hu, Jingping [1 ,2 ,3 ]
Ye, Mao [4 ,5 ,6 ]
Zhou, Zhiguang [1 ,2 ,3 ]
机构：
[1] Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha 410011, Hunan, Peoples R China
[2] Cent South Univ, Key Lab Diabet Immunol, Minist Educ, Changsha 410011, Hunan, Peoples R China
[3] Natl Clin Res Ctr Metab Dis, Changsha 410011, Hunan, Peoples R China
[4] Hunan Univ, Coll Chem & Chem Engn, Mol Sci & Biomed Lab, Changsha 410082, Hunan, Peoples R China
[5] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
[6] Hunan Univ, Collaborat Innovat Ctr Mol Engn Theranost, Coll Biol, Changsha 410082, Hunan, Peoples R China
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 2017年 / 95卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Diabetes mellitus; Aptamers; Oligonucleotides; INSULIN-RESISTANCE; DNA APTAMER; ELECTROCHEMICAL DETECTION; AUTOMATED SELECTION; MICROFLUIDIC ASSAYS; PEGAPTANIB SODIUM; ADIPOSE-TISSUE; SSDNA APTAMER; IN-VITRO; RNA;
D O I：
10.1007/s00109-016-1485-1
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Diabetes mellitus is one of the most common chronic diseases that threatens human health in worldwide populations. Despite enormous efforts invested in the study of diabetes mellitus, the development of precise diagnoses and treatments for this disease remains difficult due to the limitations of current techniques. Therefore, new methods are currently being developed. Aptamers are oligonucleotides that bind to specific target molecules and have been widely applied as diagnostic and therapeutic tools. In recent years, aptamers have been utilized in the study of diabetes mellitus and metabolic diseases. In this review, we highlight recent developments and new perspectives on aptamers in the field of diabetes mellitus and other metabolic diseases. Aptamers could potentially provide the means for efficient diagnoses and therapies against diabetes mellitus.
引用
收藏
页码：249 / 256
页数：8
相关论文
共 96 条
  • [31] Noninvasive mapping of pancreatic inflammation in recent-onset type-1 diabetes patients
    Gaglia, Jason L.
    Harisinghani, Mukesh
    Aganj, Iman
    Wojtkiewicz, Gregory R.
    Hedgire, Sandeep
    Benoist, Christophe
    Mathis, Diane
    Weissleder, Ralph
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (07) : 2139 - 2144
  • [32] Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients
    Gaglia, Jason L.
    Guimaraes, Alexander R.
    Harisinghani, Mukesh
    Turvey, Stuart E.
    Jackson, Richard
    Benoist, Christophe
    Mathis, Diane
    Weissleder, Ralph
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (01) : 442 - 445
  • [33] Post-SELEX optimization of aptamers
    Gao, Shunxiang
    Zheng, Xin
    Jiao, Binghua
    Wang, Lianghua
    [J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2016, 408 (17) : 4567 - 4573
  • [34] Retinol-binding protein 4 is associated with insulin resistance and body fat distribution in nonobese subjects without type 2 diabetes
    Gavi, Shai
    Stuart, Louise M.
    Kelly, Patricia
    Melendez, Mark M.
    Mynarcik, Dennis C.
    Gelato, Marie C.
    McNurlan, Margaret A.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (05) : 1886 - 1890
  • [35] Aptamers as radiopharmaceuticals for nuclear imaging and therapy
    Gijs, Marlies
    Aerts, An
    Impens, Nathalie
    Baatout, Sarah
    Luxen, Andre
    [J]. NUCLEAR MEDICINE AND BIOLOGY, 2016, 43 (04) : 253 - 271
  • [36] Pegaptanib Sodium for the Treatment of Proliferative Diabetic Retinopathy and Diabetic Macular Edema
    Giuliari, Gian P.
    Guel, David A.
    Gonzalez, Victor H.
    [J]. CURRENT DIABETES REVIEWS, 2009, 5 (01) : 33 - 38
  • [37] Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects
    Graham, Timothy E.
    Yang, Qin
    Blueher, Matthias
    Hammarstedt, Ann
    Ciaraldi, Theodore P.
    Henry, Robert R.
    Wason, Christopher J.
    Oberbach, Andreas
    Jansson, Per-Anders
    Smith, Ulf
    Kahn, Barbara B.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (24) : 2552 - 2563
  • [38] Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    Guilherme, Adilson
    Virbasius, Joseph V.
    Puri, Vishwajeet
    Czech, Michael P.
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (05) : 367 - 377
  • [39] Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance
    Hafner, Markus
    Schmitz, Anton
    Gruene, Imke
    Srivatsan, Seergazhi G.
    Paul, Bianca
    Kolanus, Waldemar
    Quast, Thomas
    Kremmer, Elisabeth
    Bauer, Inga
    Famulok, Michael
    [J]. NATURE, 2006, 444 (7121) : 941 - 944
  • [40] Diabetic Retinopathy: Targeting Vasoregression
    Hammes, Hans-Peter
    Feng, Yuxi
    Pfister, Frederick
    Brownlee, Michael
    [J]. DIABETES, 2011, 60 (01) : 9 - 16
12345678910