Aptamers: novel diagnostic and therapeutic tools for diabetes mellitus and metabolic diseases

被引：25
作者：
Hu, Jingping [1 ,2 ,3 ]
Ye, Mao [4 ,5 ,6 ]
Zhou, Zhiguang [1 ,2 ,3 ]
机构：
[1] Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha 410011, Hunan, Peoples R China
[2] Cent South Univ, Key Lab Diabet Immunol, Minist Educ, Changsha 410011, Hunan, Peoples R China
[3] Natl Clin Res Ctr Metab Dis, Changsha 410011, Hunan, Peoples R China
[4] Hunan Univ, Coll Chem & Chem Engn, Mol Sci & Biomed Lab, Changsha 410082, Hunan, Peoples R China
[5] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China
[6] Hunan Univ, Collaborat Innovat Ctr Mol Engn Theranost, Coll Biol, Changsha 410082, Hunan, Peoples R China
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 2017年 / 95卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Diabetes mellitus; Aptamers; Oligonucleotides; INSULIN-RESISTANCE; DNA APTAMER; ELECTROCHEMICAL DETECTION; AUTOMATED SELECTION; MICROFLUIDIC ASSAYS; PEGAPTANIB SODIUM; ADIPOSE-TISSUE; SSDNA APTAMER; IN-VITRO; RNA;
D O I：
10.1007/s00109-016-1485-1
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Diabetes mellitus is one of the most common chronic diseases that threatens human health in worldwide populations. Despite enormous efforts invested in the study of diabetes mellitus, the development of precise diagnoses and treatments for this disease remains difficult due to the limitations of current techniques. Therefore, new methods are currently being developed. Aptamers are oligonucleotides that bind to specific target molecules and have been widely applied as diagnostic and therapeutic tools. In recent years, aptamers have been utilized in the study of diabetes mellitus and metabolic diseases. In this review, we highlight recent developments and new perspectives on aptamers in the field of diabetes mellitus and other metabolic diseases. Aptamers could potentially provide the means for efficient diagnoses and therapies against diabetes mellitus.
引用
收藏
页码：249 / 256
页数：8
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