Chitosan/pectin/gum Arabic polyelectrolyte complex: Process-dependent appearance, microstructure analysis and its application

被引：68

作者：

Tsai, Ruei-Yi ^{[1
]}

Chen, Pin-Wen ^{[1
]}

Kuo, Ting-Yun ^{[1
]}

Lin, Che-Min ^{[1
]}

Wang, Da-Ming ^{[1
]}

Hsien, Tzu-Yang ^{[2
]}

Hsieh, Hsyue-Jen ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Chem Engn, Taipei 106, Taiwan

[2] China Univ Technol, Gen Educ Ctr, Taipei 116, Taiwan

来源：

CARBOHYDRATE POLYMERS | 2014年 / 101卷

关键词：

Chitosan; Pectin; Gum Arabic; Polyelectrolyte complex (PEC); Microstructure; Controlled drug release; DRUG-DELIVERY; CONTROLLED-RELEASE; CHITOSAN; PECTIN; HEMOSTASIS; STABILITY; SCAFFOLDS; GELATION; SYSTEMS; MODEL;

D O I：

10.1016/j.carbpol.2013.10.008

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Novel chitosan/pectin/gum Arabic polyelectrolyte complex (PEC) solutions and membranes with various compositions were prepared for biomedical applications. The appearance of the PEC solutions, either clear or turbid, was process-dependent and depended on how the three components were dissolved and mixed. The addition of gum Arabic to the chitosan and pectin significantly decreased the viscosities of the resultant PEC solutions due to the formation of globe-like microstructures that was accompanied by network-like microstructures and other molecular entanglements. The mechanical strength and hydrophilicity of the PEC membranes manufactured from the PEC solutions, especially for a weight ratio of 84/8/8 (chitosan/pectin/gum Arabic), were enhanced compared to pure chitosan membranes. Moreover, the use of the 84/8/8 PEC membranes as a drug carrier exhibited steady and fairly complete release of a drug (insulin) for 6 h. Based on these promising results, the chitosan/pectin/gum Arabic PEC membranes have great potential in controlled drug release applications. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：752 / 759

页数：8