Differences in Survival between Colon and Rectal Cancer from SEER Data

被引：116
作者：
Lee, Yen-Chien [1 ,2 ]
Lee, Yen-Lin [1 ,2 ]
Chuang, Jen-Pin [1 ,3 ]
Lee, Jenq-Chang [4 ]
机构：
[1] Natl Cheng Kung Univ Coll Med, Inst Clin Med, Tainan, Taiwan
[2] Tainan Hosp, Minist Hlth & Welf, Dept Oncol, Tainan, Taiwan
[3] Tainan Hosp, Minist Hlth & Welf, Dept Surg, Tainan, Taiwan
[4] Natl Cheng Kung Univ Med Ctr, Dept Surg, Tainan, Taiwan
来源：
PLOS ONE | 2013年 / 8卷 / 11期
关键词：
RAS GENE-MUTATIONS; COLORECTAL-CANCER; PHYSICAL-ACTIVITY; VITAMIN-D; RISK; METAANALYSIS; METHIONINE; SMOKING; FOLATE; CHEMORADIOTHERAPY;
D O I：
10.1371/journal.pone.0078709
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background: Little is known about colorectal cancer or colon and rectal cancer. Are they the same disease or different diseases? Objectives: The aim of this epidemiology study was to compare the features of colon and rectal cancer by using recent national cancer surveillance data. Design and setting: Data included colorectal cancer (1995-2008) from the Surveillance, Epidemiology, and End Results Program (SEER) database. Only adenocarcinoma was included for analysis. Patients: A total of 372,130 patients with a median follow-up of 32 months were analyzed. Main outcome measures: Mean survival of patients with the same stage of colon and rectal cancer was evaluated. Results: Around 35% of patients had stage information. Among them, colon cancer patients had better survival than those with rectal cancer, by a margin of 4 months in stage IIB. In stage IIIC and stage IV, rectal cancer patients had better survival than colon cancer patients, by about 3 months. Stage IIB colorectal cancer patients had a poorer prognosis than those with stage IIIA and IIIB colorectal cancer. After adjustment of age, sex and race, colon cancer patients had better survival than rectal cancer of stage IIB, but in stage IIIC and IV, rectal cancer patients had better survival than colon cancer. Limitations: The study is limited by its retrospective nature. Conclusion: This was a population-based study. The prognosis of rectal cancer was not worse than that of colon cancer. Local advanced colorectal cancer had a poorer prognosis than local regional lymph node metastasis. Stage IIB might require more aggressive chemotherapy, and no less than that for stage III.
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页数：11
相关论文
共 36 条
[1]   Differences in Protein Expression and Gene Amplification of Cyclins between Colon and Rectal Adenocarcinomas [J].
Aamodt, Rolf ;
Jonsdottir, Kristin ;
Andersen, Solveig Norheim ;
Bondi, Johan ;
Bukholm, Geir ;
Bukholm, Ida R. K. .
GASTROENTEROLOGY RESEARCH AND PRACTICE, 2009, 2009
[2]   Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer [J].
Andre, T ;
Boni, C ;
Mounedji-Boudiaf, L ;
Navarro, M ;
Tabernero, J ;
Hickish, T ;
Topham, C ;
Zaninelli, M ;
Clingan, P ;
Bridgewater, J ;
Tabah-Fisch, I ;
de Gramont, A .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (23) :2343-2351
[3]   Kirsten ras mutations in patients with colorectal cancer:: the 'RASCAL II' study [J].
Andreyev, HJN ;
Norman, AR ;
Cunningham, D ;
Oates, J ;
Dix, BR ;
Iacopetta, BJ ;
Young, J ;
Walsh, T ;
Ward, R ;
Hawkins, N ;
Beranek, M ;
Jandik, P ;
Benamouzig, R ;
Jullian, E ;
Laurent-Puig, P ;
Olschwang, S ;
Muller, O ;
Hoffmann, I ;
Rabes, HM ;
Zietz, C ;
Troungos, C ;
Valavanis, C ;
Yuen, ST ;
Ho, JWC ;
Croke, CT ;
O'Donoghue, DP ;
Giaretti, W ;
Rapallo, A ;
Russo, A ;
Bazan, V ;
Tanaka, M ;
Omura, K ;
Azuma, T ;
Ohkusa, T ;
Fujimori, T ;
Ono, Y ;
Pauly, M ;
Faber, C ;
Glaesener, R ;
de Goeij, AFPM ;
Arends, JW ;
Andersen, SN ;
Lövig, T ;
Breivik, J ;
Gaudernack, G ;
Clausen, OPF ;
De Angelis, P ;
Meling, GI ;
Rognum, TO ;
Smith, R .
BRITISH JOURNAL OF CANCER, 2001, 85 (05) :692-696
[4]   Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid [J].
Birkenkamp-Demtroder, K ;
Olesen, SH ;
Sorensen, FB ;
Laurberg, S ;
Laiho, P ;
Aaltonen, LA ;
Orntoft, TF .
GUT, 2005, 54 (03) :374-384
[5]   PREVALENCE OF RAS GENE-MUTATIONS IN HUMAN COLORECTAL CANCERS [J].
BOS, JL ;
FEARON, ER ;
HAMILTON, SR ;
VERLAANDEVRIES, M ;
VANBOOM, JH ;
VANDEREB, AJ ;
VOGELSTEIN, B .
NATURE, 1987, 327 (6120) :293-297
[6]   Smoking and Colorectal Cancer A Meta-analysis [J].
Botteri, Edoardo ;
Iodice, Simona ;
Bagnardi, Vincenzo ;
Raimondi, Sara ;
Lowenfels, Albert B. ;
Maisonneuve, Patrick .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 300 (23) :2765-2778
[7]  
Chan DSM, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0020456, 10.1371/journal.pone.0027218]
[8]   Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapy [J].
Davies, Janine M. ;
Trembath, Dimitri ;
Deal, Allison M. ;
Funkhouser, William K. ;
Calvo, Benjamin F. ;
Finnegan, Timothy ;
Weck, Karen E. ;
Tepper, Joel E. ;
O'Neil, Bert H. .
RADIATION ONCOLOGY, 2011, 6
[9]   Dietary Folate, Methionine, Riboflavin, and Vitamin B-6 and Risk of Sporadic Colorectal Cancer [J].
de Vogel, Stefan ;
Dindore, Vasundhara ;
van Engeland, Manon ;
Goldbohm, R. Alexandra ;
van den Brandt, Piet A. ;
Weijenberg, Marty P. .
JOURNAL OF NUTRITION, 2008, 138 (12) :2372-2378
[10]   KRAS AND BRAF MUTATIONS AND PTEN EXPRESSION DO NOT PREDICT EFFICACY OF CETUXIMAB-BASED CHEMORADIOTHERAPY IN LOCALLY ADVANCED RECTAL CANCER [J].
Erben, Philipp ;
Stroebel, Philipp ;
Horisberger, Karoline ;
Popa, Juliana ;
Bohn, Beatrice ;
Hanfstein, Benjamin ;
Kaehler, Georg ;
Kienle, Peter ;
Post, Stefan ;
Wenz, Frederik ;
Hochhaus, Andreas ;
Hofheinz, Ralf-Dieter .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2011, 81 (04) :1032-1038
1234