Rhodium-catalyzed asymmetric hydrogenation of β-branched enamides for the synthesis of β-stereogenic amines

被引：34

作者：

Zhang, Jian ^{[1
]}

Liu, Chong ^{[2
]}

Wang, Xingguang ^{[2
]}

Chen, Jianzhong ^{[2
]}

Zhang, Zhenfeng ^{[1
]}

Zhang, Wanbin ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 47期

基金：

中国国家自然科学基金;

关键词：

HIGHLY ENANTIOSELECTIVE HYDROGENATION; DYNAMIC KINETIC RESOLUTION; ALPHA-DEHYDROAMINO KETONES; FRIEDEL-CRAFTS ALKYLATION; BETA; BETA-DISUBSTITUTED NITROALKENES; PHOSPHORAMIDITE LIGANDS; EFFICIENT SYNTHESIS; BETA(2)-AMINO ACID; SPIRO DIPHOSPHINES; PRIMARY ALCOHOLS;

D O I：

10.1039/c8cc02798f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using a rhodiumcomplex of a bisphosphine ligand (R)-SDP, beta-branched simple enamides with a (Z)-configuration were hydrogenated to beta-stereogenic amines in quantitative yields and with excellent enantioselectivities (88-96% ee).

引用

页码：6024 / 6027

页数：4

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