Immunogenicity and Safety of the Quadrivalent Human Papillomavirus Vaccine in Girls Living With HIV

被引：1

作者：

Brophy, Jason ^{[1
]}

Bitnun, Ari ^{[2
,3
]}

Alimenti, Ariane ^{[4
]}

Lapointe, Normand ^{[5
,6
]}

Samson, Lindy ^{[1
]}

Read, Stanley ^{[2
,3
]}

Karatzios, Christos ^{[7
,8
]}

Dobson, Simon ^{[4
]}

Moses, Erin ^{[9
]}

Blitz, Sandra ^{[10
]}

Lipsky, Nancy-Grace ^{[9
]}

Ogilvie, Gina ^{[9
,11
,12
,13
]}

Walmsley, Sharon ^{[10
,14
,15
]}

Raboud, Janet ^{[10
,16
]}

Money, Deborah ^{[9
,11
,14
]}

机构：

[1] Univ Ottawa, Childrens Hosp Eastern Ontario, Dept Pediat, Ottawa, ON, Canada

[2] Univ Toronto, Dept Pediat, Toronto, ON, Canada

[3] Hosp Sick Children, Dept Pediat, Toronto, ON, Canada

[4] Univ British Columbia, Div Infect & Immunol Dis, Dept Pediat, Fac Med, Vancouver, BC, Canada

[5] Univ Montreal, Fac Med, Dept Pediat, Montreal, PQ, Canada

[6] CHU St Justine, Ctr Maternel & Infantile SIDA, Montreal, PQ, Canada

[7] Univ Montreal, Dept Paediat, Ctr Hosp Univ St Justine, Montreal, PQ, Canada

[8] McGill Univ, Dept Paediat, Montreal Childrens Hosp, Ctr Hlth, Montreal, PQ, Canada

[9] BC Womens Hosp & Hlth Ctr, Womens Hlth Res Inst, Vancouver, BC, Canada

[10] Univ Hlth Network, Toronto Gen Res Inst, Toronto, ON, Canada

[11] Univ British Columbia, Dept Obstet & Gynecol, Vancouver, BC, Canada

[12] BC Ctr Dis Control, Vancouver, BC, Canada

[13] Univ British Columbia, Dept Family Med, Fac Med, Vancouver, BC, Canada

[14] Canadian HIV Trials Network CTN, CIHR, Vancouver, BC, Canada

[15] Univ Toronto, Dept Med, Toronto, ON, Canada

[16] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2018年 / 37卷 / 06期

关键词：

HIV; HPV vaccine; pediatric; serology; immunogenicity; YOUNG-WOMEN; INFECTED CHILDREN; PARTICLE VACCINE; HPV VACCINE; ANTIBODY-RESPONSES; ADOLESCENTS; EFFICACY; IMMUNITY; DISEASES; TYPE-11;

D O I：

10.1097/INF.0000000000001874

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated quadrivalent human papillomavirus vaccine seroresponses among 35 girls living with HIV (9-13 years of ages) and compared with data on girls without HIV, as part of a subgroup analysis. The quadrivalent human papillomavirus vaccine was safe and well tolerated. However, antibody response was significantly lower in girls living with HIV relative to girls without HIV. HIV virologic suppression predicted better antibody response.

引用

页码：595 / 597

页数：3

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