Focal irreversible electroporation for prostate cancer: functional outcomes and short-term oncological control

被引:81
|
作者
Ting, F. [1 ,2 ,3 ]
Tran, M. [1 ,2 ,3 ]
Boehm, M. [2 ]
Siriwardana, A. [1 ,2 ,3 ]
Van Leeuwen, P. J. [1 ,2 ]
Haynes, A-M [2 ]
Delprado, W. [4 ]
Shnier, R. [5 ]
Stricker, P. D. [1 ,2 ,3 ]
机构
[1] St Vincents Prostate Canc Ctr, Darlinghurst, NSW, Australia
[2] Kinghorn Canc Ctr, Garvan Inst Med Res, Darlinghurst, NSW, Australia
[3] Univ New S Wales, Sch Med, Sydney, NSW, Australia
[4] Douglass Hanly Moir Pathol, Macquarie Pk, NSW, Australia
[5] Southern Radiol, Randwick, NSW, Australia
基金
英国医学研究理事会;
关键词
ABLATION; THERAPY; METAANALYSIS; TRIAL; MEN;
D O I
10.1038/pcan.2015.47
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND: Current data on the use of irreversible electroporation (IRE) in the treatment of prostate cancer (PCa) is limited. We aim to evaluate the safety, short-term functional and oncological outcomes of focal IRE in low-intermediate risk PCa. METHODS: Between February 2013 and May 2014, 32 consecutive men underwent IRE at a single centre. Patients with low-intermediate risk PCa who had not received previous PCa treatment were included for analysis. The tumour was ablated using 3-6 electrodes, ensuring a minimum 5-mm safety margin around the visible magnetic resonance imaging (MRI) lesion. Follow-up included recording Clavien complications, Expanded Prostate Cancer Index Composite (EPIC) questionnaires (baseline, 1.5, 3, 6 months), 6-month multi-parametric MRI (mp-MRI) and 7-month biopsy. Findings on mp-MRI and biopsy were sub-divided into infield, adjacent or outfield of the treatment zone. RESULTS: Twenty-five men were included for final analysis. Safety follow-up revealed one Clavien Grade 3 complication and five Grade 1 complications. Functional follow-up confirmed no significant change in American Urological Association urinary symptom score, sexual or bowel function. Infield, there were no suspicious findings on mp-MRI (n = 24) or biopsy (n = 21) in all patients. Adjacent to the treatment zone, five (21%) had suspicious findings on mp-MRI with four (19%) proving to be significant on biopsy. Outfield, there were two (8%) with suspicious findings on mp-MRI and one (5%) significant finding on biopsy. For the five patients with significant findings on follow-up biopsy, one is awaiting repeat IRE, one had radical prostatectomy and three remained on active surveillance. CONCLUSIONS: In selected patients with low-intermediate risk PCa, focal IRE appears to be safe with minimal morbidity. There were no infield recurrences and 76% of patients were histologically free of significant cancer at 8 months. Almost all recurrences were adjacent to the treatment zone, and this was addressed by widening the treatment margins.
引用
收藏
页码:46 / 52
页数:7
相关论文
共 50 条
  • [41] Comparison of short-term oncological and functional outcomes between open and robotic-assisted radical prostatectomy for localised prostate cancer in the Victorian Prostate Cancer Registry (PCR)
    Ong, W. L.
    Evans, S.
    Murphy, D.
    Kearns, P.
    Millar, J.
    BJU INTERNATIONAL, 2015, 115 : 28 - 29
  • [42] Survival and functional and oncological outcomes following intersphincteric resection for low rectal cancer: short-term results
    Molnar, Calin
    Butiurca, Vlad-Olimpiu
    Botoncea, Marian
    Toganel, Cornelia
    Gurzu, Simona
    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2018, 46 (04) : 1617 - 1625
  • [43] Role of robotic surgery for rectal cancer: short-term, functional, and oncological outcomes for 150 consecutive patients
    Kr, A.
    P, S. S.
    Kumar, R. C.
    ANNALS OF ONCOLOGY, 2019, 30
  • [44] Salvage Local Treatments After Focal Therapy with Irreversible Electroporation for Prostate Cancer
    Blazevski, Alexandar
    Amin, Amer
    Scheltema, Matthijs J.
    Cusick, Tom
    Haynes, Anne-Maree
    Thompson, James
    Stricker, Phillip
    ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2019, 15 : 44 - 44
  • [45] Focal Irreversible Electroporation (IRE) as a primary and salvage treatment for localised prostate cancer
    Siriwardana, A.
    Van den Bos, W.
    Kalsbeek, A.
    Thompson, J.
    Ting, F.
    Bohm, M.
    Haynes, A-M.
    Shnier, R.
    Delprado, W.
    Stricker, P.
    BJU INTERNATIONAL, 2017, 119 : 37 - 38
  • [46] FOCAL IRREVERSIBLE ELECTROPORATION FOR MANAGEMENT OF LOCALIZED PROSTATE CANCER. INITIAL RESULTS
    Enikeev, Dmitry
    Chinenov, Denis
    Laukhtina, Ekaterina
    Taratkin, Mark
    Perekalina, Anna
    Rapoport, Leonid
    Glybochko, Petr
    JOURNAL OF UROLOGY, 2020, 203 : E1307 - E1307
  • [47] Functional outcomes and oncological control after focal therapy for localized clinically significant prostate cancer: Outcomes of a phase II prospective trial in focal cryotherapy
    Tan, Yu Guang
    Ngo, Nye Thane
    Law, Yan Mee
    Yuen, John S. P.
    Khor, L. Y.
    Tuan, Jeffrey K. L.
    Chua, Melvin L. K.
    Ho, Henry S. S.
    Polascik, T.
    Tay, K. J.
    INTERNATIONAL JOURNAL OF UROLOGY, 2022, 29 : 26 - 26
  • [48] Irreversible Electroporation for the Ablation of Prostate Cancer
    Karagiannis, Andreas
    Varkarakis, John
    CURRENT UROLOGY REPORTS, 2019, 20 (10)
  • [49] Advances in irreversible electroporation for prostate cancer
    Liu, Xinyu
    Wang, Hao
    Zhao, Zilin
    Zhong, Qikai
    Wang, Xinlei
    Liu, Xing
    Chen, Junzhi
    Han, Conghui
    Shi, Zhenduo
    Liang, Qing
    DISCOVER ONCOLOGY, 2024, 15 (01)
  • [50] Irreversible Electroporation for the Ablation of Prostate Cancer
    Andreas Karagiannis
    John Varkarakis
    Current Urology Reports, 2019, 20