One-Electron Reduction of Penicillins in Relation to the Oxidative Stress Phenomenon

被引：6

作者：

Szabo, Laszlo ^{[1
,2
]}

Toth, Tuende ^{[2
]}

Takacs, Erzsebet ^{[1
,3
]}

Wojnarovits, Laszlo ^{[1
]}

机构：

[1] Hungarian Acad Sci, Energy Res Ctr, Inst Energy Secur & Environm Safety, H-1121 Budapest, Hungary

[2] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1111 Budapest, Hungary

[3] Obuda Univ, Sandor Rejto Fac Light Ind & Environm Engn, H-1034 Budapest, Hungary

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2015年 / 16卷 / 12期

关键词：

antibiotic; penicillin; oxidative stress; reactive oxygen species; reduction; hydrated electron; ketyl radical; pulse radiolysis; BETA-LACTAM ANTIBIOTICS; PULSE-RADIOLYSIS; AQUEOUS-SOLUTION; HYDRATED ELECTRONS; BACTERICIDAL ANTIBIOTICS; AMINO-ACIDS; PEPTIDES; PROTEINS; RADICALS; CONFORMATION;

D O I：

10.3390/ijms161226130

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Certain bactericidal antibiotics target mitochondrial components and, due to the leakage of electrons from the electron transport chain, one-electron reduction might occur that can lead to intermediates passing the electron to suitable acceptors. This study aimed at investigating the one-electron reduction mechanism of selected penicillin derivatives using pulse radiolysis techniques. Penicillins can accommodate the electron on each of their carbonyl carbon. Ketyl radicals are thus produced, which are reducing agents with possibility to interact with suitable biomolecules. A detailed mechanism of the reduction is reported.

引用

页码：29673 / 29681

页数：9

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