Analysis of tau haplotypes in Pick's disease

被引：39

作者：

Morris, HR

Baker, M

Yasojima, K

Houlden, H

Khan, MN

Wood, NW

Hardy, J

Grossman, M

Trojanowski, J

Revesz, T

Bigio, EH

Bergeron, C

Janssen, JC

McGeer, PL

Rossor, MN

Lees, AJ

Lantos, PL

Hutton, M

机构：

[1] Mayo Clin Jacksonville, Jacksonville, FL 32224 USA

[2] UCL, Dementia Res Grp, London, England

[3] UCL, Neurol Inst, London, England

[4] UCL, Dept Neuropathol, London, England

[5] UCL, Inst Psychiat, London, England

[6] UCL, Reta Lila Weston Inst Neurol Studies, London, England

[7] Ctr Res Neurodegenerat Dis, Toronto, ON, Canada

[8] Univ British Columbia, Kinsmen Lab Neurol Res, Vancouver, BC V5Z 1M9, Canada

[9] Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX USA

[10] Hosp Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[11] Hosp Univ Penn, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA

[12] Hosp Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

NEUROLOGY | 2002年 / 59卷 / 03期

关键词：

D O I：

10.1212/WNL.59.3.443

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Pick's disease (PiD) is characterized by the deposition of tau protein as three-repeat tau Pick bodies, whereas progressive supranuclear palsy (PSP) involves the deposition of four-repeat tau neurofibrillary tangles. PSP is associated with the tau HI haplotype. The authors investigated a possible association between PiD and the tau H1 or H2 haplotype. There was no difference between the tau H2 haplotype or H2H2 genotype frequency in PiD cases and control subjects. No tau mutations were identified in pathologically typical cases of PiD, with antibody 12-E8-negative Pick bodies.

引用

页码：443 / 445

页数：3

共 11 条

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