The role of notch signaling in bone development and disease

被引：31

作者：

Yavropoulou, Maria P. ^{[1
]}

Yovos, John G. ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, HEPA Univ Hosp, Mol Endocrinol Lab, Div Endocrinol & Metab,Dept Med 1, GR-54006 Thessaloniki, Greece

来源：

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM | 2014年 / 13卷 / 01期

关键词：

Bone; Cartilage; Notch signaling; Osteoblasts; Osteoclasts; HAJDU-CHENEY-SYNDROME; OSTEOBLASTIC CELL-DIFFERENTIATION; CAUSES SPONDYLOCOSTAL DYSOSTOSIS; AXIAL SKELETON DEVELOPMENT; ALAGILLE-SYNDROME; CHONDROCYTE DIFFERENTIATION; ARTERIOHEPATIC DYSPLASIA; OSTEOCLAST PRECURSORS; MISSENSE MUTATIONS; ABNORMAL FORMATION;

D O I：

10.1007/BF03401318

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

During the last decade a considerable amount of data have been accumulated regarding the role of intracellular signaling pathways in the pathogenesis of human diseases. One of these, Notch signaling, well known for its significance in cellular development and tissue morphogenesis, has been increasingly recognized as a crucial participant in the pathogenetic mechanisms underlying certain skeletal disorders. A better understanding of the biology and regulation of this multifaceted pathway is considered an important step towards clarification of the pathogenesis of various skeletal diseases and the development of novel targets for therapeutic purposes.

引用

页码：24 / 37

页数：14

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