Phylogeographic patterns of the yellow fever virus around the metropolitan region of Sao Paulo, Brazil, 2016-2019

被引:4
作者
Cunha, Marielton dos Passos [1 ]
Duarte-Neto, Amaro Nunes [2 ]
Pour, Shahab Zaki [1 ]
de Souza Pereira, Barbara Brito [1 ]
Ho, Yeh-Li [3 ]
Perondi, Beatriz [4 ]
Sztajnbok, Jaques [5 ]
Ferreira Alves, Venancio Avancini [2 ]
Ferraz da Silva, Luiz Fernando [2 ,6 ]
Dolhnikoff, Marisa [2 ]
Nascimento Saldiva, Paulo Hilario [2 ]
de Andrade Zanotto, Paolo Marinho [1 ]
机构
[1] Univ Sao Paulo, Biomed Sci Inst, Dept Microbiol, Lab Mol Evolut & Bioinformat, Sao Paulo, Brazil
[2] Univ Sao Paulo, Fac Med, Pathol Dept, Sao Paulo, Brazil
[3] Univ Sao Paulo, Div Clin Infect & Parasit Dis, Fac Med, Clin Hosp,Intens Care Unit, Sao Paulo, Brazil
[4] Univ Sao Paulo, Clin Hosp, Fac Med, Yellow Fever Crisis Comm, Sao Paulo, Brazil
[5] Inst Infectol Emilio Ribas, Sao Paulo, Brazil
[6] Univ Sao Paulo, Serv Verificat Deaths Capital, Sao Paulo, Brazil
来源
PLOS NEGLECTED TROPICAL DISEASES | 2022年 / 16卷 / 09期
基金
巴西圣保罗研究基金会;
关键词
POPULATION-DYNAMICS; MODEL; INFERENCE; ALIGNMENT;
D O I
10.1371/journal.pntd.0010705
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
From 2016 to 2019, the largest outbreak caused by the Yellow Fever virus (YFV) in the 21(st) century in the Americas occurred in southeastern Brazil. A sylvatic cycle of transmission was reported near densely populated areas, such as the large metropolitan area of the city of Sao Paulo. Here, we describe the origin, spread, and movement of the YFV throughout the state of Sao Paulo. Whole-genome sequences were obtained from tissues of two patients who died due to severe yellow fever, during 2018-2019. Molecular analysis indicated that all analyzed tissues were positive for YFV RNA, with the liver being the organ with the highest amount of viral RNA. Sequence analysis indicates that genomes belonged to the South American genotype I and were grouped in the epidemic clade II, which includes sequences from the states of Goias, Minas Gerais, and Sao Paulo of previous years. The analysis of viral dispersion indicates that the outbreak originated in Goias at the end of 2014 and reached the state of Sao Paulo through the state of Minas Gerais after 2016. When the virus reached near the urban area, it spread towards both the east and south regions of the state, not establishing an urban transmission cycle in the metropolitan region of Sao Paulo. The virus that moved towards the east met with YFV coming from the south of the state of Rio de Janeiro, and the YFV that was carried to the south reached the Brazilian states located in the south region of the country.
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页数:16
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