Exit Strategies: S1P Signaling and T Cell Migration

被引：123

作者：

Baeyens, Audrey ^{[1
]}

Fang, Victoria ^{[1
]}

Chen, Cynthia ^{[1
]}

Schwab, Susan R. ^{[1
]}

机构：

[1] NYU, Sch Med, Skirball Inst Biomol Med, New York, NY 10016 USA

来源：

TRENDS IN IMMUNOLOGY | 2015年 / 36卷 / 12期

关键词：

SPHINGOSINE 1-PHOSPHATE RECEPTOR; SPHINGOSINE-1-PHOSPHATE TRANSPORTER SPNS2; LYMPHOCYTE EGRESS; TISSUE; TRAFFICKING; EXPRESSION; RETENTION; FTY720; INFECTION; MAINTAINS;

D O I：

10.1016/j.it.2015.10.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Whereas the role of sphingosine 1-phosphate receptor 1 (S1PR1) in T cell egress and the regulation of S1P gradients between lymphoid organs and circulatory fluids in homeostasis are increasingly well understood, much remains to be learned about S1P signaling and distribution during an immune response. Recent data suggest that the role of S1PR1 in directing cells from tissues into circulatory fluids is reprised again and again, particularly in guiding activated T cells from non-lymphoid tissues into lymphatics. Conversely, S1P receptor 2 (S1PR2), which antagonizes migration towards chemokines, confines cells within tissues. Here we review the current understanding of the roles of S1P signaling in activated T cell migration. In this context, we outline open questions, particularly regarding the shape of S1P gradients in different tissues in homeostasis and inflammation, and discuss recent strategies to measure S1P.

引用

页码：778 / 787

页数：10

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