The association of 22 Y chromosome short tandem repeat loci with initiative-aggressive behavior

被引：6

作者：

Yang, Chun ^{[1
]}

Ba, Huajie ^{[2
]}

Zhang, Wei ^{[3
,4
,5
]}

Zhang, Shuyou ^{[1
]}

Zhao, Hanqing ^{[1
]}

Yu, Haiying ^{[1
]}

Gao, Zhiqin ^{[1
]}

Wang, Binbin ^{[3
,4
,5
]}

机构：

[1] 102 Hosp Peoples Liberat Army, Psychiat Ctr Chinese Peoples Liberat Army, Dept Psychiat, Changzhou 213003, Jiangsu, Peoples R China

[2] Publ Secur Bur Changzhou, DNA Lab, Changzhou 213003, Jiangsu, Peoples R China

[3] Ctr Genet, Beijing 100081, Peoples R China

[4] Natl Res Inst Family Planning, Dept Judicial Identificat, Beijing 100081, Peoples R China

[5] Peking Union Med Coll, Grad Sch, Beijing, Peoples R China

来源：

GENE | 2018年 / 654卷

关键词：

Initiative-aggressive behavior; Y chromosome; Short tandem repeats; Genetic polymorphism; Case-control study; PERSONALITY; IMPULSIVITY; INPATIENT; OTHERS; SYSTEM;

D O I：

10.1016/j.gene.2018.02.039

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aggressive behavior represents an important public concern and a clinical challenge to behaviorists and psychiatrists. Aggression in humans is known to have an important genetic basis, so to investigate the association of Y chromosome short tandem repeat (Y-STR) loci with initiative-aggressive behavior, we compared allelic and haplotypic distributions of 22 Y-STRs in a group of Chinese males convicted of premeditated extremely violent crimes (n = 271) with a normal control group (n = 492). Allelic distributions of DYS533 and DYS437 loci differed significantly between the two groups (P <. 0.05). The case group had higher frequencies of DYS533 allele 14, DYS437 allele 14, and haplotypes 11-14 of DYS533-DYS437 compared with the control group. Additionally, the DYS437 allele 15 frequency was significantly lower in cases than controls. No frequency differences were observed in the other 20 Y-STR loci between these two groups. Our results indicate a genetic role for Y-STR loci in the development of initiative aggression in non-psychiatric subjects.

引用

页码：10 / 13

页数：4