The association of 22 Y chromosome short tandem repeat loci with initiative-aggressive behavior

被引:6
|
作者
Yang, Chun [1 ]
Ba, Huajie [2 ]
Zhang, Wei [3 ,4 ,5 ]
Zhang, Shuyou [1 ]
Zhao, Hanqing [1 ]
Yu, Haiying [1 ]
Gao, Zhiqin [1 ]
Wang, Binbin [3 ,4 ,5 ]
机构
[1] 102 Hosp Peoples Liberat Army, Psychiat Ctr Chinese Peoples Liberat Army, Dept Psychiat, Changzhou 213003, Jiangsu, Peoples R China
[2] Publ Secur Bur Changzhou, DNA Lab, Changzhou 213003, Jiangsu, Peoples R China
[3] Ctr Genet, Beijing 100081, Peoples R China
[4] Natl Res Inst Family Planning, Dept Judicial Identificat, Beijing 100081, Peoples R China
[5] Peking Union Med Coll, Grad Sch, Beijing, Peoples R China
关键词
Initiative-aggressive behavior; Y chromosome; Short tandem repeats; Genetic polymorphism; Case-control study; PERSONALITY; IMPULSIVITY; INPATIENT; OTHERS; SYSTEM;
D O I
10.1016/j.gene.2018.02.039
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Aggressive behavior represents an important public concern and a clinical challenge to behaviorists and psychiatrists. Aggression in humans is known to have an important genetic basis, so to investigate the association of Y chromosome short tandem repeat (Y-STR) loci with initiative-aggressive behavior, we compared allelic and haplotypic distributions of 22 Y-STRs in a group of Chinese males convicted of premeditated extremely violent crimes (n = 271) with a normal control group (n = 492). Allelic distributions of DYS533 and DYS437 loci differed significantly between the two groups (P <. 0.05). The case group had higher frequencies of DYS533 allele 14, DYS437 allele 14, and haplotypes 11-14 of DYS533-DYS437 compared with the control group. Additionally, the DYS437 allele 15 frequency was significantly lower in cases than controls. No frequency differences were observed in the other 20 Y-STR loci between these two groups. Our results indicate a genetic role for Y-STR loci in the development of initiative aggression in non-psychiatric subjects.
引用
收藏
页码:10 / 13
页数:4
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