MITF is a critical regulator of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in malignant melanoma

被引：12

作者：

Ullrich, Nico ^{[1
,2
]}

Loeffek, Stefanie ^{[1
,2
]}

Horn, Susanne ^{[1
,2
]}

Ennen, Marie ^{[3
]}

Sanchez-del-Campo, Luis ^{[4
]}

Zhao, Fang ^{[1
,2
]}

Breitenbuecher, Frank ^{[2
,5
]}

Davidson, Irwin ^{[3
]}

Singer, Bernhard B. ^{[6
]}

Schadendorf, Dirk ^{[1
,2
]}

Goding, Colin R. ^{[4
]}

Helfrich, Iris ^{[1
,2
]}

机构：

[1] Univ Duisburg Essen, W German Canc Ctr, Fac Med, Skin Canc Unit,Dept Dermatol, Essen, Germany

[2] German Canc Consortium DKTK, Essen, Germany

[3] Inst Genet & Biol Mol & Cellulaire, Illkirch Graffenstaden, France

[4] Univ Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford, England

[5] West German Canc Ctr, Dept Med Oncol, Essen, Germany

[6] Univ Duisburg Essen, Univ Hosp, Inst Anat, Essen, Germany

来源：

PIGMENT CELL & MELANOMA RESEARCH | 2015年 / 28卷 / 06期

关键词：

microphthalmia-associated transcription factor; carcinoembryonic antigen-related cell adhesion molecule 1; M-box motif; melanoma; RED HAIR; VARIANTS; SKIN; EXPRESSION;

D O I：

10.1111/pcmr.12414

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The multifunctional Ig-like carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is neo-expressed in the majority of malignant melanoma lesions. CEACAM1 acts as a driver of tumor cell invasion, and its expression correlates with poor patient prognosis. Despite its importance in melanoma progression, how CEACAM1 expression is regulated is largely unknown. Here, we show that CEACAM1 expression in melanoma cell lines and melanoma tissue strongly correlates with that of the microphthalmia-associated transcription factor (MITF), a key regulator of melanoma proliferation and invasiveness. MITF is revealed as a direct and positive regulator for CEACAM1 expression via binding to an M-box motif located in the CEACAM1 promoter. Taken together, our study provides novel insights into the regulation of CEACAM1 expression and suggests an MITF-CEACAM1 axis as a potential determinant of melanoma progression.

引用

页码：736 / 740

页数：5

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